Subcategory Detail
Interagency Autism Coordinating Committee (IACC) logo
Office of Autism Research Coordination (OARC) logo

Model Systems/Therapeutic Targets$24,115,793.04
Fiscal Year: 2010
  

Download 2010 Model Systems/Therapeutic Targets projects (EXCEL)
Animal models mimicking behaviors of ASD and those that are being used to develop or test new drug treatments, as well as cell lines used to discover new drug targets or to screen potential drug candidates, are included in this subcategory.
Graph: The subcategories for Question 4 illustrate the many approaches to treatments and interventions supported by autism research funders. The largest amount of funding supported projects to develop Model systems and therapeutic targets (35%), followed by research on Behavioral interventions (29%). Medical/Pharmacologic interventions received 16% of funding, classroom-based interventions (Educational) received 10% of funding, and Technology-based interventions and supports received 7% of funding. The subcategories with the smallest amounts of funding included Occupational, physical, and sensory-based (2%) and Complementary, dietary, and alternative (1%).
Note: Initial Sort is by Principal Investigator. Sorting by other columns is available by clicking on the desired column header.
Project Title Principal Investigator Strategic Plan Objective Institution
Interaction between MEF2 and MECP2 in the pathogenesis of autism spectrum disorders -2 Nakanishi, Nobuki Q4.S.B Burnham Institute
Systematic analysis of neural circuitry in mouse models of autism Osten, Pavel Q4.S.B Cold Spring Harbor Laboratory
Role of L-type calcium channels in hippocampal neuronal network activity Owen, Scott Q4.S.B Stanford University
Novel probiotic therapies for autism Patterson, Paul Q4.S.B California Institute of Technology
Preclinical testing of novel oxytocin receptor activators in models of autism phenotypes Pedersen, Cort Q4.S.B University of North Carolina at Chapel Hill
Small-molecule compounds for treating autism spectrum disorders Philpot, Ben Q4.S.B The University of North Carolina at Chapel Hill
Neurogenetic model of social behavior heterogeneity in autism spectrum disorders Platt, Michael Q4.S.B Duke University
High-resolution diffusion tensor imaging in mouse models relevant to autism Poptani, Harish Q4.S.B University of Pennsylvania
Animal models of autism: Pathogenesis and treatment Powell, Craig Q4.S.B University of Texas Southwestern Medical Center
Novel genetic animal models of autism Powell, Craig Q4.S.B University of Texas Southwestern Medical Center
Neuroligin function in vivo: Implications for autism and mental retardation Powell, Craig Q4.S.B University of Texas Southwestern Medical Center
Genetic models of serotonin transporter regulation linked to mental disorders Ramamoorthy, Sammanda Q4.S.B Medical University of South Carolina
Role of a novel Wnt pathway in autism spectrum disorders Reichardt, Louis Q4.S.B University of California, San Francisco
A novel cell-based assay for autism research and drug discovery Restifo, Linda Q4.S.B University of Arizona
Caspr2 dysfunction in autism spectrum disorders Robbins, Elissa Q4.S.B Yale University
Design & synthesis of novel CNS-active oxytocin and vasopressin receptor ligands Roberts, Edward Q4.Other The Scripps Research Institute
Novel strategies to manipulate Ube3a expression for the treatment of autism and Angelman syndrome Roth, Bryan Q4.S.B University of North Carolina at Chapel Hill
Methods for production of ICSI and SCNT derived macaque stem cells Schatten, Gerald Q4.S.B Southwest Foundation For Biomedical Research
Optimization of methods for production of both ICSI- and SCNT derived baboon embryonic stem cells Schatten, Gerald Q4.S.B Southwest Foundation For Biomedical Research
Micro-RNA regulation in pluripotent stem cells Schatten, Gerald Q4.S.B Southwest Foundation For Biomedical Research
Novel, subtype selective potentiators of nicotinic acetycholine receptors Schulte, Marvin Q4.Other University of Alaska Fairbanks
Dissecting the neural control of social attachment Shah, Nirao Q4.S.B University of California, San Francisco
Mice lacking Shank postsynaptic scaffolds as an animal model of autism Sheng, Morgan Q4.S.B Massachusetts Institute of Technology
Using zebrafish and chemical screening to define function of autism genes Sive, Hazel Q4.S.B Whitehead Institute for Biomedical Research
Characterization of autism susceptibility genes on chromosome 15q11-13 Smith, Stephen Q4.S.B Beth Israel Deaconess Medical Center