Subcategory Detail
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Molecular Pathways$28,759,657.25
Fiscal Year: 2010
  

Download 2010 Molecular Pathways projects (EXCEL)
This subcategory includes studies on specific molecules and proteins (other than the immune and metabolic systems) that may be involved in the development of ASD and related genetic disorders (e.g., fragile X syndrome and Rett syndrome). Many of these projects use animal and cellular models to explore the biological effects of specific candidate genes and to identify common molecular pathways, including alterations in synaptic functioning and intracellular signaling cascades.
Graph: Question 2 encompassed a broad range of biological research, resulting in the need to create a larger number of subcategories to adequately describe the breadth of research than was required for other Strategic Plan Questions. The subcategory with the largest portion of funding was Molecular pathways (32%), followed by Neural systems and Subgroups/Biosignatures, which each received less than half the funding of Molecular pathways (15% and 14%, respectively). Projects related to Developmental trajectory were supported by 11% of 2010 ASD research funding, and research on Sensory and motor function received 7%. Studies on Immune/Metabolic pathways (6%), Co-occurring conditions (5%), Cognitive studies (5%), and Computational science (4%) round out the types of research in Question 2.
Note: Initial Sort is by Principal Investigator. Sorting by other columns is available by clicking on the desired column header.
Project Title Principal Investigator Strategic Plan Objective Institution
Glial control of neuronal receptive ending morphology Shaham, Shai Q2.Other The Rockefeller University
Role of neuronal migration genes in synaptogenesis and plasticity Sudarov, Anamaria Q2.Other Weill Cornell Medical College
A systematic test of the relation of ASD heterogeneity to synaptic function Sudhof, Thomas; Malenka, Robert Q2.Other Stanford University
Kinetics of drug macromolecule complex formation Taylor, Palmer Q2.Other University of California, San Diego
Imaging PTEN-induced changes in adult cortical structure and function in vivo Trachtenberg, Joshua Q2.Other University of California, Los Angeles
Brain lipid rafts in cholesterol biosynthesis disorders Yu, Hongwei Q2.Other Medical College of Wisconsin
Autism and the insula: Genomic and neural circuits Allman, John Q2.Other California Institute of Technology
Regulation of activity-dependent ProSAP2 synaptic dynamics Rowan, Magali Q2.Other Stanford University
Perturbed activity-dependent plasticity mechanisms in autism Sabatini, Bernardo Q2.Other Harvard Medical School
Studies on protein synthesis and long-term adaptive responses in the CNS Smith, Carolyn Q2.Other National Institutes of Health
Function and dysfunction of neuroligins in synaptic circuits Sudhof, Thomas Q2.Other Stanford University
Function of neurexins Sudhof, Thomas Q2.Other Stanford University
ACE Center: Cognitive affective and neurochemical processes underlying is in autism Sweeney, John Q2.Other University of Illinois at Chicago
Imaging synaptic neurexin-neuroligin complexes by proximity biotinylation: Applications to the molecular pathogenesis of autism Thyagarajan, Amar Q2.Other Massachusetts Institute of Technology
Regulation of synaptogenesis by cyclin-dependent kinase 5 Tsai, Li-Huei Q2.Other Massachusetts Institute of Technology
Role of micro-RNAs in ASD affected circuit formation and function Ullian, Erik Q2.Other University of California, San Francisco
Morphogenesis and function of the cerebral cortex Vaccarino, Flora Q2.Other Yale University
Genetic studies of autism-related Drosophila neurexin and neuroligin Bhat, Manzoor Q2.Other The University of North Carolina at Chapel Hill
Role of autism-susceptibility gene, CNTNAP2, in neural circuitry for vocal communication White, Stephanie Q2.Other University of California, Los Angeles
Imaging signal transduction in single dendritic spines Yasuda, Ryohei Q2.Other Duke University
Young development of a novel PET ligand for detecting oxytocin receptors in brain Young, Larry Q2.Other Emory University
High-throughput DNA sequencing method for probing the connectivity of neural circuits at single-neuron resolution Zador, Anthony Q2.Other Cold Spring Harbor Laboratory
BDNF secretion and neural precursor migration Zhao, Xuesong Q2.Other Dana-Farber Cancer Institute
Functional analysis of neurexin IV in Drosophila Zipursky, Larry Q2.Other University of California, Los Angeles
Identification of candidate genes at the synapse in autism spectrum disorders Gupta, Abha Q2.Other Yale University