Subcategory Detail
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Molecular Pathways$28,759,657.25
Fiscal Year: 2010
  

Download 2010 Molecular Pathways projects (EXCEL)
This subcategory includes studies on specific molecules and proteins (other than the immune and metabolic systems) that may be involved in the development of ASD and related genetic disorders (e.g., fragile X syndrome and Rett syndrome). Many of these projects use animal and cellular models to explore the biological effects of specific candidate genes and to identify common molecular pathways, including alterations in synaptic functioning and intracellular signaling cascades.
Graph: Question 2 encompassed a broad range of biological research, resulting in the need to create a larger number of subcategories to adequately describe the breadth of research than was required for other Strategic Plan Questions. The subcategory with the largest portion of funding was Molecular pathways (32%), followed by Neural systems and Subgroups/Biosignatures, which each received less than half the funding of Molecular pathways (15% and 14%, respectively). Projects related to Developmental trajectory were supported by 11% of 2010 ASD research funding, and research on Sensory and motor function received 7%. Studies on Immune/Metabolic pathways (6%), Co-occurring conditions (5%), Cognitive studies (5%), and Computational science (4%) round out the types of research in Question 2.
Note: Initial Sort is by Principal Investigator. Sorting by other columns is available by clicking on the desired column header.
Project Title Principal Investigator Strategic Plan Objective Institution
Neuroligins and neurexins as autism candidate genes: Study of their association in synaptic connectivity Comoletti, Davide Q2.Other University of California, San Diego
Cellular characterization of Caspr2 Comoletti, Davide Q2.Other University of California, San Diego
Kinetics of drug macromolecule complex formation Taylor, Palmer Q2.Other University of California, San Diego
A systems biology approach to unravel the underlying functional modules of ASD Iakoucheva, Lilia Q2.Other University of California, San Diego
A sex-specific dissection of autism genetics Weiss, Lauren Q2.S.B University of California, San Francisco
A sex-specific dissection of autism genetics Weiss, Lauren Q2.S.B University of California, San Francisco
Analysis of Fgf17 roles and regulation in mammalian forebrain development Hoch, Renee Q2.Other University of California, San Francisco
Role of micro-RNAs in ASD affected circuit formation and function Ullian, Erik Q2.Other University of California, San Francisco
Roles of Wnt signaling/scaffolding molecules in autism Okerlund, Nathan Q2.Other University of California, San Francisco
Autism-specific mutation in DACT1: Impact on brain development in a mouse model Cheyette, Benjamin Q2.Other University of California, San Francisco
Molecular basis of autism associated with human adenylosuccinate lyase gene defects Colman, Roberta Q2.S.D University of Delaware
Self-injurious behavior: An animal model of an autism endophenotype Devine, Darragh Q2.Other University of Florida
Serotonin signal transduction in two groups of autistic patients Rasenick, Mark Q2.Other University of Illinois at Chicago
ACE Center: Cognitive affective and neurochemical processes underlying is in autism Sweeney, John Q2.Other University of Illinois at Chicago
Synaptic phenotype, development, and plasticity in the fragile X mouse Cox, Charles Q2.S.D University of Illinois at Urbana Champaign
The microRNA pathway in translational regulation of neuronal development Gao, Fen-Biao Q2.S.D University of Massachusetts Medical School
Homeostatic regulation of presynaptic function by dendritic mTORC1 Henry, Fredrick Q2.Other University of Michigan
GABAergic dysfunction in autism Fatemi, Seyyed Q2.Other University of Minnesota
Regulation of 22q11 genes in embryonic and adult forebrain Lamantia, Anthony Q2.S.D University of North Carolina at Chapel Hill
Functional circuit disorders of sensory cortex in ASD and RTT Carlson, Gregory Q2.S.D University of Pennsylvania
Engrailed and the control of synaptic circuitry in drosophila Blagburn, Jonathan Q2.Other University of Puerto Rico Medical Sciences Campus
Met signaling in neural development and circuitry formation Qiu, Shenfeng Q2.Other University of Southern California
Function and structure adaptations in forebrain development Levitt, Pat Q2.Other University of Southern California
Proteomics in drosophila to identify autism candidate substrates of UBE3A Reiter, Lawrence Q2.S.D University of Tennessee Health Science Center
Regulation of synapse elimination by FMRP Wilkerson, Julia Q2.S.D University of Texas Southwestern Medical Center