Subcategory Detail
Interagency Autism Coordinating Committee (IACC) logo
Office of Autism Research Coordination (OARC) logo

Immune/Metabolic Pathways$5,385,744.28
Fiscal Year: 2010
  

Download 2010 Immune/Metabolic Pathways projects (EXCEL)
These projects focus on understanding the biological mechanisms of metabolism and the immune system that may be altered in autism, typically in cells and animal models. This largely includes studies on inflammation and inflammatory molecules (i.e., cytokines), as well as on the role of mitochondria, energy metabolism, and oxidative stress. Also included in this group are projects seeking to identify specific immune and metabolic triggers in early prenatal and post-natal life, such as maternal infection, maternal auto-antibodies, and toxic exposures.
Graph: Question 2 encompassed a broad range of biological research, resulting in the need to create a larger number of subcategories to adequately describe the breadth of research than was required for other Strategic Plan Questions. The subcategory with the largest portion of funding was Molecular pathways (32%), followed by Neural systems and Subgroups/Biosignatures, which each received less than half the funding of Molecular pathways (15% and 14%, respectively). Projects related to Developmental trajectory were supported by 11% of 2010 ASD research funding, and research on Sensory and motor function received 7%. Studies on Immune/Metabolic pathways (6%), Co-occurring conditions (5%), Cognitive studies (5%), and Computational science (4%) round out the types of research in Question 2.
Note: Initial Sort is by Principal Investigator. Sorting by other columns is available by clicking on the desired column header.
Project Title Principal Investigator Strategic Plan Objective Institution
Systematic characterization of the immune response to gluten and casein in autism spectrum disorders Alaedini, Armin Q2.S.A Weill Cornell Medical College
Molecular pathways involved in oxidative stress and leaky gut impairment in autism spectrum disorders Antonucci, Nicola Q2.S.A University of Naples
Primate models of autism Bauman, Melissa Q2.S.A University of California, Davis
Primate models of autism Bauman, Melissa; Amaral, David Q2.S.A University of California, Davis
An ex-vivo placental perfusion system to study materno-fetal biology Bonnin, Alexandre Q2.S.A University of Southern California
CNS toxicity of ambient air pollution: Postnatal exposure to ultrafine particles Cory-Slechta, Deborah Q2.S.A University of Rochester
Early biologic markers for autism Croen, Lisa Q2.S.A Kaiser Permanente Division of Research
Study of anti-neuronal autoantibodies in behavioral and movement disorders Cunningham, Madeleine Q2.S.A University of Oklahoma Health Sciences Center
Review of the literature on selenocysteine metabolism and selenoproteins in autism Deth, Richard Q2.Other Northeastern University School of Pharmacy
The pathogenesis of autism: Maternal antibody exposure in the fetal brain Diamond, Betty Q2.S.A The Feinstein Institute for Medical Research
A role for immune molecules in cortical connectivity: Potential implications for autism Elmer, Bradford Q2.S.A University of California, Davis
Is autism a mitochondrial disease? Giulivi, Cecilia Q2.S.A University of California, Davis
Redox abnormalities as a vulnerability phenotype for autism and related alterations in CNS development Hepel, Maria Q2.S.A State University of New York at Potsdam
How does IL-6 mediate the development of autism-related behaviors? Hsiao, Elaine Q2.S.A California Institute of Technology
Redox abnormalities as a vulnerability phenotype for autism and related alterations in CNS development James, Sandra Q2.S.A Arkansas Children's Hospital Research Institute
Th cell polarization and candida reactivity in autistic children with food allergy Jyonouchi, Harumi Q2.S.E University of Medicine & Dentistry of New Jersey
Regulation of inflammatory Th17 cells in autism spectrum disorder Littman, Dan Q2.S.A New York University School of Medicine
Maternal immune activation, cytokines, and the pathogenesis of autism McAllister, A. Kimberley Q2.S.A University of California, Davis
Immune molecules and cortical synaptogenesis: Possible implications for the pathogenesis of autism McAllister, A. Kimberley Q2.S.A University of California, Davis
Prostaglandins and cerebellum development McCarthy, Margaret Q2.S.A University of Maryland, Baltimore
Influence of oxidative stress on transcription and alternative splicing of methionine synthase in autism Muratore, Christina Q2.S.A Northeastern University
Redox abnormalities as a vulnerability phenotype for autism and related alterations in CNS development Noble, Mark Q2.S.A University of Rochester
Maternal infection and autism: Impact of placental sufficiency and maternal inflammatory responses on fetal brain development Palmer, Theo Q2.S.A Stanford University
Neurological diseases due to inborn errors of metabolism Pascual, Juan Q2.S.A University of Texas Southwestern Medical Center
A non-human primate autism model based on maternal immune activation Patterson, Paul Q2.S.A University of California, Davis