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Interagency Autism Coordinating Committee (IACC)
Autism Research Database
Office of Autism Research Coordination (OARC)
 
Project Element Element Description

Project Title

Project Title

Extracellular signal-related kinase biomarker development in autism

Principal Investigator

Principal Investigator

Erickson, Craig

Description

Description

Despite sharing a common set of behaviors, persons with autism spectrum disorders (ASDs) vary widely. This variation has made targeted treatment development difficult. The development of ways to subgroup persons with ASDs based upon biological data would be useful to ASD treatment development. Extracellular signal-related kinase (ERK) is an enzyme (protein) that plays important roles in brain cell signaling and growth. ERK activity is known to be abnormal as measured in the blood of persons with fragile X syndrome (FXS), a common single gene cause of autism. Recent finding from ASD research all point to potential ERK abnormalities in persons with ASDs of unknown cause. ERK activity has to date not been measured in persons with ASDs of unknown cause. This proposal aims to help develop better a better means to define potential subgroups of people with ASDs who may respond to specific treatments by measuring ERK activity in the blood of persons with ASDs. This proposal will take the first step towards studying ERK activity in ASDs by studying ERK activity in blood samples from 36 persons with ASDs (divided equally into 5-11, 12-17, and 18-25 year old groups) compared to values in control subjects who are IQ-, gender-, and age-matched to the participants with ASDs. Subjects with ASD and intellectual disability will also be matched to an age- and gender-matched neurotypical peer so we can help determine if any ERK abnormalities are related specifically to ASDs or more generally to intellectual disability. This project will provide the initial information needed to continue to develop study of ERK activity in ASDs including potential use of ERK study in targeted drug treatment studies as a means to determine which patients may most benefit from a potential new treatment.

Funder

Funder

Simons Foundation

Fiscal Year Funding

Fiscal Year Funding

0

Current Award Period

Current Award Period

2012-2015

Strategic Plan Question

Strategic Plan Question

Question 1: When Should I Be Concerned?

Strategic Plan Objective

Strategic Plan Objective

Green dot: Objective has greater than or equal to the recommended funding. 1LB. Develop at least five measures of behavioral and/or biological heterogeneity in children or adults with ASD, beyond variation in intellectual disability, that clearly relate to etiology and risk, treatment response and/or outcome by 2015. IACC Recommended Budget: $71,100,000 over 5 years.

Project Link

Project Link

Extracellular signal-related kinase biomarker development in autism (External web link)

Institution

Institution

Cincinnati Children's Hospital

State/Country

State/Country

Ohio

Project Number

Project Number

237650

Federal or Private?

Federal or Private?

Private

Received ARRA Funding?

Received ARRA Funding?

No

History/Related Projects

History/Related Projects

Extracellular signal-related kinase biomarker development in autism | 60889 | 2012 | 237650
Extracellular signal-related kinase biomarker development in autism | 115779 | 2013 | 237650
Extracellular signal-related kinase biomarker development in autism | 54890 | 2014 | 237650

 
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