Skip to content
Interagency Autism Coordinating Committee (IACC)
Autism Research Database
Office of Autism Research Coordination (OARC)
 
Project Element Element Description

Project Title

Project Title

A Prospective Birth Cohort Study on Pre- and Peri-natal Determinants of Autism Spectrum Disorders and Developmental Disabilities

Principal Investigator

Principal Investigator

Wang, Xiaobin

Description

Description

An existing large-scale prospective birth cohort – the Boston Birth Cohort (BBC) – is transformed into an ASD cohort to efficiently and immediately investigate preconception, pre- and peri-natal risk factors and health services patterns for ASD. The BBC is a well-established and ongoing prospective birth cohort of a U.S. urban predominantly low-income minority population, now consisting of over 8,500 mother-infant pairs. The goal is to examine the independent and combined effects of maternal demographics, medical, psychosocial, home and neighborhood environments at critical developmental windows (preconception, pre- and perinatal) on the risk of ASD and Developmental Disabilities (DD), and to analyze health services patterns in this cohort.

Funder

Funder

Health Resources and Services Administration

Fiscal Year Funding

Fiscal Year Funding

499997

Current Award Period

Current Award Period

2014-2016

Strategic Plan Question

Strategic Plan Question

Question 3: What Caused This To Happen And Can This Be Prevented?

Strategic Plan Objective

Strategic Plan Objective

Green dot: Objective has greater than or equal to the recommended funding. 3SH. Support at least three studies of special populations or use existing databases to inform our understanding of environmental risk factors for ASD in pregnancy and the early postnatal period by 2012. Such studies could include: o Comparisons of populations differing in geography, gender, ethnic background, exposure history (e.g., prematurity, maternal infection, nutritional deficiencies, toxins), and migration patterns; and o Comparisons of phenotype (e.g., cytokine profiles), in children with and without a history of autistic regression, adverse events following immunization (such as fever and seizures), and mitochondrial impairment. These studies may also include comparisons of phenotype between children with regressive ASD and their siblings. Emphasis on environmental factors that influence prenatal and early postnatal development is particularly of high priority. Epidemiological studies should pay special attention to include racially and ethnically diverse populations. IACC Recommended Budget: $12,000,000 over 5 years.

Project Link

Project Link

A Prospective Birth Cohort Study on Pre- and Peri-natal Determinants of Autism Spectrum Disorders and Developmental Disabilities (External web link)

Institution

Institution

Johns Hopkins University

State/Country

State/Country

Maryland

Project Number

Project Number

R40MC27443

Federal or Private?

Federal or Private?

Federal

Received ARRA Funding?

Received ARRA Funding?

No

History/Related Projects

History/Related Projects

A Prospective Birth Cohort Study on Pre- and Peri-natal Determinants of Autism Spectrum Disorders and Developmental Disabilities | 499999 | 2014 | R40MC27443

 
Back to Top