One theory to explain the causes and symptoms of ASD is an imbalance between excitatory and inhibitory signals in the brain. Some brain cells may be too turned on, or not turned on enough. As a result, signals may not be relayed across the brain properly, including in areas associated with ASD, resulting in autism symptoms. This may explain some of the behavioral features of ASD, but this theory has not been demonstrated with data. Dr. Foss-Feig will engage participants on a number of behavioral tasks, and at the same time, non-invasively measure brain activity in real time to look at how different regions are connected. The new funding will be used to build on a study of this mechanism in schizophrenia and apply the methods to study autism. This will also allow the researchers to better understand the differences and similarities between autism and schizophrenia, so new treatment strategies, including pharmacologic therapies, can be00 tested.