Skip to content
Interagency Autism Coordinating Committee (IACC)
Autism Research Database
Office of Autism Research Coordination (OARC)
 
Project Element Element Description

Project Title

Project Title

Signaling Pathways that Regulate Excitatory-inhibitory Balance

Principal Investigator

Principal Investigator

Bloodgood, Brenda L.

Description

Description

Autism spectrum disorder ASD) is a highly heritable collection of developmental disorders that are typified by difficulties with social interactions, communication deficits and a tendency to engage in repetitive behaviors. Significant research has suggested ASD emerges from an imbalance of excitatory and inhibitory circuit activity within various brain regions yet few molecules have been described that may directly mediate this processes. We are studying a transcription factor called NPAS4, which is expressed in neurons in response to increased excitatory activity. When NPAS4 is expressed, it regulates a set of genes that alter the number and distribution of inhibitory synapses that form on that neuron. Thus, NPAS4 senses excitation and regulates inhibition, acting as a master regulator of excitatory-inhibitory balance. We are combining optogenetic strategies for activating neurons with whole genome analysis and live imaging to determine how excitatory-inhibitory balance is regulated in a neuron. Our goal is to identify new pathways and molecules that will be therapeutically useful for the treatment of autism and other disorders that emerge from and imbalance of excitation and inhibition.

Funder

Funder

Brain & Behavior Research Foundation

Fiscal Year Funding

Fiscal Year Funding

30000

Current Award Period

Current Award Period

2015-2017

Strategic Plan Question

Strategic Plan Question

Question 2: How Can I Understand What Is Happening?

Strategic Plan Objective

Strategic Plan Objective

2O. Not specific to Question 2 objectives

Project Link

Project Link

No link available.

Institution

Institution

University of California, San Diego

State/Country

State/Country

California

Project Number

Project Number

Federal or Private?

Federal or Private?

Private

Received ARRA Funding?

Received ARRA Funding?

No

History/Related Projects

History/Related Projects

Signaling Pathways that Regulate Excitatory-inhibitory Balance | 0 | 2014 |

 
Back to Top