Skip to content
Interagency Autism Coordinating Committee (IACC)
Autism Research Database
Office of Autism Research Coordination (OARC)
 
Project Element Element Description

Project Title

Project Title

The role of Shank3 in neocortex versus striatum and the pathophysiology of autism

Principal Investigator

Principal Investigator

Bey, Alexandra

Description

Description

Genetic studies indicate that SHANK3, an ASD causative gene encoding a scaffolding protein at the postsynaptic density represents one of the best opportunities to dissect the pathophysiology of ASD. Studies of various isoform-specific Shank3 knockout (KO) mice support these mice as valid models. These studies also suggest that brain regions may differentially contribute to the expression of ASD-related behaviors. However, because existing Shank3 mutant mice are not brain region-specific and not complete KO, meaning that only some Shank3 isoforms are missing and the mutation is throughout the whole brain, causality between different brain regions and ASD-like behaviors cannot be firmly established without a new mouse model. The long term goal of this project is to define anatomic regions implicated in behavioral manifestations of ASD. This will illuminate potential regions, circuits, and signaling pathways to focus development of potential treatments. The central hypothesis is that deficiency of all Shank3 isoforms in the principle cells of cortex/hippocampus versus the principle cells of the striatum will contribute to different core ASD-like behaviors.

Funder

Funder

Autism Science Foundation

Fiscal Year Funding

Fiscal Year Funding

0

Current Award Period

Current Award Period

2014-2015

Strategic Plan Question

Strategic Plan Question

Question 2: How Can I Understand What Is Happening?

Strategic Plan Objective

Strategic Plan Objective

Green dot: Objective has greater than or equal to the recommended funding. 2SD. Launch three studies that target improved understanding of the underlying biological pathways of genetic conditions related to autism (e.g. Fragile X, Rett syndrome, tuberous sclerosis complex) and how these conditions inform risk assessment and individualized intervention by 2012. IACC Recommended Budget: $9,000,000 over 5 years.

Project Link

Project Link

The role of Shank3 in neocortex versus striatum and the pathophysiology of autism (External web link)

Institution

Institution

Duke University

State/Country

State/Country

North Carolina

Project Number

Project Number

Federal or Private?

Federal or Private?

Private

Received ARRA Funding?

Received ARRA Funding?

No

History/Related Projects

History/Related Projects

The Role of Shank3 in Neocortex Versus Striatum and the Pathophysiology of Autism | 0 | 2014 |
The Role of Shank3 in Neocortex Versus Striatum and the Pathophysiology of Autism | 25000 | 2013 | n/a
The role of Shank3 in neocortex versus striatum and the pathophysiology of autism | 25000 | 2014 |

 
Back to Top