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Interagency Autism Coordinating Committee (IACC)
Autism Research Database
Office of Autism Research Coordination (OARC)
 

Strategic Plan Objectives

Current 2008 projects and their funding status for each question or objective is indicated within the table by colored green dot yellow dot red dot page green dot pale yellow dot dots next to the objective. Expand for moredown arrow

Any objective colored green has greater than or equal to the recommended funding; any objective colored yellow has some degree of funding, but less than the recommended amount; while any objective colored red has no funding.

Objectives whose overarching aim (e.g., the ultimate goal of the research, irrespective of the number of projects or the budget for the objective) were achieved/partially achieved either in a previous year, with less annual funding than was recommended, or with funding that was not captured in the portfolio analyses, are colored pale green/pale yellow

The percentages noted in parentheses in the "Projects" and "Funding" columns indicate the fraction of all projects or funding within that specific question, whereas the percentage in the "Percent of Total ASD Funding" column indicates the percent of the entire ASD research funding portfolio for 2009.

Data includes 2010 funding from Federal/private funders of ASD research and 2010 ARRA funding.

Question 1: When Should I Be Concerned?Total: 29123209

IACC Strategic Plan Objectives Number of
Projects
Funding % of Total
Funding

IACC Strategic Plan Objective

yellow dot 1.1 Develop, with existing tools, at least one efficient diagnostic instrument (e.g., briefer, less time intensive) that is valid in diverse populations for use in large-scale studies by 2011. IACC Recommended Budget: $5,300,000 over 2 years.

Number of Projects

2 projects
(2%)

Funding

75000
(0%)

% of Total Funding

<1%

IACC Strategic Plan Objective

yellow dot 1.2 Validate and improve the sensitivity and specificity of new or existing screening tools for detecting ASD through studies of the following community populations that are diverse in terms of age, socio-economic status, race, ethnicity and level of functioning by 2012. IACC Recommended Budget: $5,400,000 over 3 years. o School aged children o General population (vs. clinical population)

Number of Projects

8 projects
(7%)

Funding

1246922
(4%)

% of Total Funding

1%

IACC Strategic Plan Objective

yellow dot 1.3 Identify a panel of biomarkers that separately, or in combination with behavioral measures, accurately identify, before age 2, one or more subtypes of children at risk for developing ASD by 2014. IACC Recommended Budget: $33,300,000 over 5 years.

Number of Projects

14 projects
(13%)

Funding

2885940
(10%)

% of Total Funding

1%

IACC Strategic Plan Objective

yellow dot 1.4 Develop at least five measures of behavioral and/or biological heterogeneity in children or adults with ASD, beyond variation in intellectual disability, that clearly relate to etiology and risk, treatment response and/or outcome by 2015. IACC Recommended Budget: $71,100,000 over 5 years.

Number of Projects

18 projects
(17%)

Funding

5773203
(20%)

% of Total Funding

3%

IACC Strategic Plan Objective

yellow dot 1.5 Identify and develop measures to assess at least three continuous dimensions of ASD symptoms and severity that can be used by practitioners and/or parents to assess response to intervention for people with ASD across the lifespan by 2016. IACC Recommended Budget: $18,500,000 over 5 years.

Number of Projects

2 projects
(2%)

Funding

912159
(3%)

% of Total Funding

<1%

IACC Strategic Plan Objective

1O. Not specific to Question 1 objectives

Number of Projects

63 projects
(59%)

Funding

18229985
(63%)

% of Total Funding

8%

Total Funding for Question 1

Total Funding for Question 1

Number of Projects

107 projects

Funding

29123209

% of Total Funding

13%

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Question 2: How Can I Understand What Is Happening?Total: 40621403

IACC Strategic Plan Objectives Number of
Projects
Funding % of Total
Funding

IACC Strategic Plan Objective

yellow dot 2.1 Establish an international network of biobanks for the collection of brain and other tissue (e.g., skin fibroblasts) with acquisition sites that use standardized protocols for phenotyping, collection and distribution of tissue by 2011.  IACC Recommended Budget: $10,500,000 over 2 years.

Number of Projects

1 projects
(0%)

Funding

4318579
(11%)

% of Total Funding

2%

IACC Strategic Plan Objective

green dot 2.2 Support at least four research projects to identify mechanisms of metabolic and/or immune system interactions with the central nervous system that may underlie the development of ASD during prenatal-postnatal life by 2010. IACC Recommended Budget: $9,800,000 over 4 years.

Number of Projects

18 projects
(9%)

Funding

3377568
(8%)

% of Total Funding

2%

IACC Strategic Plan Objective

red dot 2.3 Launch three studies that specifically focus on the neurodevelopment of females with ASD by 2011. IACC Recommended Budget: $8,900,000 over 5 years.

Number of Projects

0 projects
(0%)

Funding

0
(0%)

% of Total Funding

0%

IACC Strategic Plan Objective

red dot 2.4 Identify ways to increase awareness among the autism spectrum community of the potential value of brain and tissue donation to further basic research. IACC Recommended Budget: $1,400,000 over 2 years.

Number of Projects

0 projects
(0%)

Funding

0
(0%)

% of Total Funding

0%

IACC Strategic Plan Objective

yellow dot 2.5 Complete a large-scale, multi-disciplinary, collaborative project that longitudinally and comprehensively examines how the biological, clinical, and developmental profiles of children, with a special emphasis on females, youths, and adults with ASD change over time as compared to typically developing people by 2020. IACC Recommended Budget: $126,200,000 over 12 years.

Number of Projects

49 projects
(24%)

Funding

8523806
(21%)

% of Total Funding

4%

IACC Strategic Plan Objective

yellow dot 2.6 Maintain an international network of biobanks and support continued collection of brain and other tissue. IACC Recommended Budget: $22,200,000 over 5 years.

Number of Projects

1 projects
(0%)

Funding

700000
(2%)

% of Total Funding

<1%

IACC Strategic Plan Objective

2O. Not specific to Question 2 objectives

Number of Projects

134 projects
(66%)

Funding

23701450
(58%)

% of Total Funding

11%

Total Funding for Question 2

Total Funding for Question 2

Number of Projects

203 projects

Funding

40621403

% of Total Funding

18%

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Question 3: What Caused This To Happen And Can This Be Prevented?Total: 82846620

IACC Strategic Plan Objectives Number of
Projects
Funding % of Total
Funding

IACC Strategic Plan Objective

yellow dot 3.1 Initiate studies on at least five environmental factors identified in the recommendations from the 2007 IOM report “Autism and the Environment: Challenges and Opportunities for Research” as potential causes of ASD by 2010. IACC Recommended Budget: $23,600,000 over 2 years.

Number of Projects

19 projects
(9%)

Funding

7600673
(9%)

% of Total Funding

3%

IACC Strategic Plan Objective

yellow dot 3.2 Coordinate and implement the inclusion of approximately 20,000 subjects for genome-wide association studies, as well as a sample of 1,200 for sequencing studies to examine more than 50 candidate genes by 2011. IACC Recommended Budget: $43,700,000 over 4 years.

Number of Projects

14 projects
(6%)

Funding

4065392
(5%)

% of Total Funding

2%

IACC Strategic Plan Objective

yellow dot 3.3 Within the highest priority categories of exposures for ASD, identify and standardize at least three measures for identifying markers of environmental exposure in biospecimens by 2011. IACC Recommended Budget: $3,500,000 over 3 years.

Number of Projects

4 projects
(2%)

Funding

713227
(1%)

% of Total Funding

<1%

IACC Strategic Plan Objective

yellow dot 3.4 Initiate efforts to expand existing large case-control and other studies to enhance capabilities for targeted gene – environment research by 2011. IACC Recommended Budget: $27,800,000 over 5 years.

Number of Projects

4 projects
(2%)

Funding

4703867
(6%)

% of Total Funding

2%

IACC Strategic Plan Objective

yellow dot 3.5 Enhance existing case-control studies to enroll broad ethnically diverse populations affected by ASD by 2011. IACC Recommended Budget: $3,300,000 over 5 years.

Number of Projects

2 projects
(1%)

Funding

84628
(0%)

% of Total Funding

<1%

IACC Strategic Plan Objective

yellow dot 3.6 Determine the effect of at least five environmental factors on the risk for subtypes of ASD in the pre- and early postnatal period of development by 2015. IACC Recommended Budget: $25,100,000 over 7 years.

Number of Projects

13 projects
(6%)

Funding

1803628
(2%)

% of Total Funding

1%

IACC Strategic Plan Objective

green dot 3.7 Conduct a multi-site study of the subsequent pregnancies of 1,000 women with a child with ASD to assess the impact of environmental factors in a period most relevant to the progression of ASD by 2014. IACC Recommended Budget: $11,100,000 over 5 years.

Number of Projects

1 projects
(0%)

Funding

2742999
(3%)

% of Total Funding

1%

IACC Strategic Plan Objective

green dot 3.8 Identify genetic risk factors in at least 50% of people with ASD by 2014. IACC Recommended Budget: $33,900,000 over 6 years.

Number of Projects

83 projects
(38%)

Funding

37043410
(45%)

% of Total Funding

17%

IACC Strategic Plan Objective

green dot 3.9 Support ancillary studies within one or more large-scale, population-based surveillance and epidemiological studies, including U.S. populations, to collect nested, case-control data on environmental factors during preconception, and during prenatal and early postnatal development, as well as genetic data, that could be pooled (as needed), to analyze targets for potential gene/environment interactions by 2015. IACC Recommended Budget: $44,400,000 over 5 years.

Number of Projects

29 projects
(13%)

Funding

17297788
(21%)

% of Total Funding

8%

IACC Strategic Plan Objective

3O. Not specific to Question 3 objectives

Number of Projects

52 projects
(24%)

Funding

6791008
(8%)

% of Total Funding

3%

Total Funding for Question 3

Total Funding for Question 3

Number of Projects

221 projects

Funding

82846620

% of Total Funding

37%

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Question 4: Which Treatments And Interventions Will Help?Total: 53968973

IACC Strategic Plan Objectives Number of
Projects
Funding % of Total
Funding

IACC Strategic Plan Objective

yellow dot 4.1 Launch at least four research projects that seek to identify biological signatures that measure significant changes in ASD core symptoms across the lifespan by 2010. IACC Recommended Budget: $12,700,000 over 4 years.

Number of Projects

5 projects
(3%)

Funding

1047768
(2%)

% of Total Funding

<1%

IACC Strategic Plan Objective

green dot 4.2 Support at least three randomized controlled trials that address co-occurring medical conditions associated with ASD by 2010. IACC Recommended Budget: $13,400,000 over 3 years.

Number of Projects

5 projects
(3%)

Funding

4583171
(8%)

% of Total Funding

2%

IACC Strategic Plan Objective

green dot 4.3 Conduct five randomized controlled trials of early intervention for infants and toddlers by 2011. IACC Recommended Budget: $16,700,000 over 5 years.

Number of Projects

16 projects
(9%)

Funding

8071787
(15%)

% of Total Funding

4%

IACC Strategic Plan Objective

green dot 4.4 Launch three randomized controlled trials of interventions for school-aged and/or adolescents by 2012. IACC Recommended Budget: $15,600,000 over 5 years.

Number of Projects

30 projects
(17%)

Funding

4037729
(7%)

% of Total Funding

2%

IACC Strategic Plan Objective

green dot 4.5 Standardize and validate at least 20 model systems (e.g. cellular and/or animal) that replicate features of ASD and will allow identification of specific molecular targets or neural circuits amenable to existing or new interventions by 2012. IACC Recommended Budget: $75,000,000 over 5 years.

Number of Projects

42 projects
(24%)

Funding

15879827
(29%)

% of Total Funding

7%

IACC Strategic Plan Objective

yellow dot 4.6 Test safety and efficacy of at least five widely used interventions (e.g., nutrition, medications, medical procedures) that have not been rigorously studied for use in ASD by 2012. IACC Recommended Budget: $27,800,000 over 5 years.

Number of Projects

8 projects
(4%)

Funding

641285
(1%)

% of Total Funding

<1%

IACC Strategic Plan Objective

green dot 4.7 Complete two multi-site randomized controlled trials of comprehensive early intervention that address core symptoms, family functioning and community involvement by 2013. IACC Recommended Budget: $16,700,000 over 5 years.

Number of Projects

5 projects
(3%)

Funding

4236869
(8%)

% of Total Funding

2%

IACC Strategic Plan Objective

yellow dot 4.8 Complete at least three randomized controlled trials on medications targeting core symptoms in people with ASD of all ages by 2014. IACC Recommended Budget: $22,200,000 over 5 years.

Number of Projects

12 projects
(7%)

Funding

1380376
(3%)

% of Total Funding

1%

IACC Strategic Plan Objective

yellow dot 4.9 Develop interventions for siblings of people with ASD with the goal of reducing risk recurrence by at least 30% by 2014. IACC Recommended Budget: $6,700,000 over 5 years.

Number of Projects

1 projects
(1%)

Funding

14256
(0%)

% of Total Funding

<1%

IACC Strategic Plan Objective

4O. Not specific to Question 4 objectives

Number of Projects

54 projects
(30%)

Funding

14075905
(26%)

% of Total Funding

6%

Total Funding for Question 4

Total Funding for Question 4

Number of Projects

178 projects

Funding

53968973

% of Total Funding

24%

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Question 5: Where Can I Turn For Services?Total: 4156222

IACC Strategic Plan Objectives Number of
Projects
Funding % of Total
Funding

IACC Strategic Plan Objective

yellow dot 5.1 Initiate a “State of the States” assessment of existing state programs and supports for people and families living with ASD by 2009. IACC Recommended Budget: $630,000 over 2 years.

Number of Projects

6 projects
(43%)

Funding

311670
(7%)

% of Total Funding

<1%

IACC Strategic Plan Objective

red dot 5.2 Support two studies that assess how variations and access to services affect family functioning in diverse populations by 2012. IACC Recommended Budget: $1,000,000 over 3 years.

Number of Projects

0 projects
(0%)

Funding

0
(0%)

% of Total Funding

0%

IACC Strategic Plan Objective

red dot 5.3 Test the efficacy and cost-effectiveness of at least four evidence-based services for people with ASD of all ages in community settings by 2015. IACC Recommended Budget: $16,700,000 over 5 years.

Number of Projects

0 projects
(0%)

Funding

0
(0%)

% of Total Funding

0%

IACC Strategic Plan Objective

yellow dot 5.4 Test four methods to improve dissemination of effective interventions in diverse community settings by 2013. IACC Recommended Budget: $7,000,000 over 5 years.

Number of Projects

3 projects
(21%)

Funding

2596838
(62%)

% of Total Funding

1%

IACC Strategic Plan Objective

5O. Not specific to Question 5 objectives

Number of Projects

5 projects
(36%)

Funding

1247714
(30%)

% of Total Funding

1%

Total Funding for Question 5

Total Funding for Question 5

Number of Projects

14 projects

Funding

4156222

% of Total Funding

2%

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Question 6: What Does the Future Hold?Total: 7325491

IACC Strategic Plan Objectives Number of
Projects
Funding % of Total
Funding

IACC Strategic Plan Objective

green dot 6.1 Develop and have available to the research community means by which to merge or link databases that allow for tracking the involvement of people in ASD research by 2010. IACC Recommended Budget: $1,300,000 over 2 years.

Number of Projects

4 projects
(50%)

Funding

6767808
(92%)

% of Total Funding

3%

IACC Strategic Plan Objective

yellow dot 6.2 Launch at least two studies to assess and characterize variation in adults living with ASD (e.g., social and daily functioning, demographic, medical and legal status) by 2011. IACC Recommended Budget: $5,000,000 over 3 years.

Number of Projects

1 projects
(13%)

Funding

60000
(1%)

% of Total Funding

<1%

IACC Strategic Plan Objective

yellow dot 6.3 Conduct at least two clinical trials to test the efficacy and cost-effectiveness of interventions, services and supports to optimize daily functioning (e.g., educational, vocational, recreational, and social experiences) for adolescents, adults, or seniors living with ASD by 2012. IACC Recommended Budget: $8,000,000 over 5 years.

Number of Projects

1 projects
(13%)

Funding

30000
(0%)

% of Total Funding

<1%

IACC Strategic Plan Objective

red dot 6.4 Conduct a needs assessment to determine how to merge or link administrative and/or surveillance databases that allow for tracking the involvement of people living with ASD in health care, education, and social services by 2009. IACC Recommended Budget: $520,000 over 1 year.

Number of Projects

0 projects
(0%)

Funding

0
(0%)

% of Total Funding

0%

IACC Strategic Plan Objective

red dot 6.5 Develop at least two community-based interventions with individual specificity that improves outcomes, as measured by educational, occupational, and social achievements by 2015. IACC Recommended Budget: $12,900,000 over 5 years.

Number of Projects

0 projects
(0%)

Funding

0
(0%)

% of Total Funding

0%

IACC Strategic Plan Objective

red dot 6.6 Develop and have available to the research community means by which to merge or link administrative databases that allow for tracking the involvement of people living with ASD research in health care, education, and social services by 2018. IACC Recommended Budget and Time Frame: To Be Determined.

Number of Projects

0 projects
(0%)

Funding

0
(0%)

% of Total Funding

0%

IACC Strategic Plan Objective

red dot 6.7 Conduct a cost/benefit analysis on provision of services and interventions over the lifespan with regard to long-term benefits including employment, productivity, and the need for federal/state assistance. IACC Recommended Budget: $2,300,000 over 3 years.

Number of Projects

0 projects
(0%)

Funding

0
(0%)

% of Total Funding

0%

IACC Strategic Plan Objective

6O. Not specific to Question 6 objectives

Number of Projects

2 projects
(25%)

Funding

467683
(6%)

% of Total Funding

<1%

Total Funding for Question 6

Total Funding for Question 6

Number of Projects

8 projects

Funding

7325491

% of Total Funding

3%

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Not specific to SP Questions: Not specific to Strategic Plan QuestionsTotal: 4173424

IACC Strategic Plan Objectives Number of
Projects
Funding % of Total
Funding

IACC Strategic Plan Objective

Other

Number of Projects

14 projects
(100%)

Funding

4173424
(100%)

% of Total Funding

2%

Total Funding for Not specific to SP Questions

Total Funding for Not specific to SP Questions

Number of Projects

14 projects

Funding

4173424

% of Total Funding

2%

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