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Interagency Autism Coordinating Committee (IACC)
Autism Research Database
Office of Autism Research Coordination (OARC)
 
Project Element Element Description

Project Title

Project Title

Mechanisms of synaptic alterations in a neuroinflammation model of autism

Principal Investigator

Principal Investigator

Dunaevsky, Anna

Description

Description

The hypothesis is that altered expression of cytokines and chemokines in the brains of offspings exposed to maternal immune activation (MIA) results in impaired synaptic development and altered behavior. Specific aims are: 1) Study how synapses are altered in offspring challenged with MIA; 2) Study the synapses development in the presence of chemokines and cytokines; 3) Determine if alteration in synapse and social behavior can be altered by anti-neuroinflammatory drug.

Funder

Funder

Department of Defense - Army

Fiscal Year Funding

Fiscal Year Funding

0

Current Award Period

Current Award Period

2013-2016

Strategic Plan Question

Strategic Plan Question

Question 2: How Can I Understand What Is Happening?

Strategic Plan Objective

Strategic Plan Objective

Green dot: Objective has greater than or equal to the recommended funding. 2SA. Support at least four research projects to identify mechanisms of fever, metabolic and/or immune system interactions with the central nervous system that may influence ASD during prenatal-postnatal life by 2010. IACC Recommended Budget: $9,800,000 over 4 years. (Fever studies to be started by 2012.)

Project Link

Project Link

Mechanisms of synaptic alterations in a neuroinflammation model of autism (External web link)

Institution

Institution

University of Nebraska Medical Center

State/Country

State/Country

Nebraska

Project Number

Project Number

AR120096

Federal or Private?

Federal or Private?

Federal

Received ARRA Funding?

Received ARRA Funding?

No

History/Related Projects

History/Related Projects

Mechanisms of synaptic alterations in a neuroinflammation model of autism | 579882 | 2012 | AR120096
Mechanisms of synaptic alterations in a neuroinflammation model of autism | 0 | 2015 | AR120096
Mechanisms of synaptic alterations in a neuroinflammation model of autism | 0 | 2014 | AR120096

 
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