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Interagency Autism Coordinating Committee (IACC)
Autism Research Database
Office of Autism Research Coordination (OARC)
 
Project Element Element Description

Project Title

Project Title

Convergence of immune and genetic signaling pathways in autism and schizophrenia

Principal Investigator

Principal Investigator

Barrow, Stephanie

Description

Description

Stephanie L. Barrow, Ph.D., of the University of California, Davis, is exploring the convergence of immune and genetic signaling pathways in autism spectrum disorder and schizophrenia. Many of the genetic mutations associated with these disorders converge on a common molecular pathway in the cerebral cortex. Environmental factors have also been implicated in both disorders, many of which alter immune function, but it remains unclear whether genetic mutations and immune dysregulation utilize overlapping or independent pathways. Identification of a common pathway affected in both autism and schizophrenia as a result of genetic mutations and environmental exposures could have significant implications for the treatment of both disorders.

Funder

Funder

Brain & Behavior Research Foundation

Fiscal Year Funding

Fiscal Year Funding

29430

Current Award Period

Current Award Period

2013-2015

Strategic Plan Question

Strategic Plan Question

Question 2: How Can I Understand What Is Happening?

Strategic Plan Objective

Strategic Plan Objective

Green dot: Objective has greater than or equal to the recommended funding. 2SA. Support at least four research projects to identify mechanisms of fever, metabolic and/or immune system interactions with the central nervous system that may influence ASD during prenatal-postnatal life by 2010. IACC Recommended Budget: $9,800,000 over 4 years. (Fever studies to be started by 2012.)

Project Link

Project Link

No link available.

Institution

Institution

University of California, Davis

State/Country

State/Country

California

Project Number

Project Number

Federal or Private?

Federal or Private?

Private

Received ARRA Funding?

Received ARRA Funding?

No

History/Related Projects

History/Related Projects

Convergence of immune and genetic signaling pathways in autism and schizophrenia | 0 | 2012 | N/A

 
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