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Interagency Autism Coordinating Committee (IACC)
Autism Research Database
Office of Autism Research Coordination (OARC)
 
Project Element Element Description

Project Title

Project Title

Role of astrocytic glutamate transporter GLT1 in Fragile X

Principal Investigator

Principal Investigator

Higashimori, Haruki

Description

Description

One of the crucial functions of astrocytes in the healthy brain is to maintain very low levels of the excitatory neurotransmitter, glutamate. This is accomplished by removal of excess glutamate through specialized glutamate transporters, such as GLT1, which are specifically found on astrocytes. Recently, we discovered that Fragile X Syndrome (FXS) mice have fewer and more dysfunctional GLT1 transporters. In this mini-grant we propose to expand on our findings in the rodent brain. We propose to evaluate human brain tissue samples to assess whether there is a similar alteration in human glutamate transporter in FXS and autism patients. This study will be the first to address whether human astrocyte dysfunction contributes to the development of FXS, and may identify an important new target for restoration of normal brain development in both FXS and autism patients.

Funder

Funder

Autism Science Foundation

Fiscal Year Funding

Fiscal Year Funding

5000

Current Award Period

Current Award Period

2013-2014

Strategic Plan Question

Strategic Plan Question

Question 2: How Can I Understand What Is Happening?

Strategic Plan Objective

Strategic Plan Objective

Green dot: Objective has greater than or equal to the recommended funding. 2SD. Launch three studies that target improved understanding of the underlying biological pathways of genetic conditions related to autism (e.g. Fragile X, Rett syndrome, tuberous sclerosis complex) and how these conditions inform risk assessment and individualized intervention by 2012. IACC Recommended Budget: $9,000,000 over 5 years.

Project Link

Project Link

Role of astrocytic glutamate transporter GLT1 in Fragile X (External web link)

Institution

Institution

Tufts University

State/Country

State/Country

Massachusetts

Project Number

Project Number

n/a

Federal or Private?

Federal or Private?

Private

Received ARRA Funding?

Received ARRA Funding?

No

History/Related Projects

History/Related Projects

Role of astrocytic glutamate transporter GLT1 in Fragile X | 0 | 2014 |
Role of astrocytic glutamate transporter GLT1 in fragile X | 40000 | 2012 | N/A
Role of astrocytic glutamate transporter GLT1 in fragile X | 0 | 2013 | n/a

 
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