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Interagency Autism Coordinating Committee (IACC)
Autism Research Database
Office of Autism Research Coordination (OARC)
 
Project Element Element Description

Project Title

Project Title

Molecular analysis of gene-environment interactions in the intestines of children with autism

Principal Investigator

Principal Investigator

Williams, Brent

Description

Description

Gastrointestinal (GI) disturbances are commonly reported in children with autism, complicate clinical management and may contribute to behavioral impairment. Evidence of inflammation and anecdotal reports of improvement in some children following dietary modification, antibiotics and probiotics led us to profile host gene expression and to survey the microbiome in intestinal biopsies of children with autism and GI disturbances (AUT-GI) compared to children with normal neurological development and GI disturbances The intestine must maximize nutritional uptake of dietary components while maintaining a barrier to toxins and infectious agents. Dysregulation of intestinal homeostasis can have a profound impact on the gastrointestinal system, but can also manifest peripherally and influence overall human health. The investigators’ previous research identified deficiencies in gene pathways involved in carbohydrate digestion in addition to changes in intestinal bacteria in biopsies from children with autism and GI disturbances. This project aims to investigate the extent to which other microbes, such as fungi and viruses, or other gene pathways, such those involved in inflammation, are associated with GI disturbances in autism. The findings promise to enhance our understanding of gene-environment interactions in autistic children with GI disturbances and provide a scientific foundation for rigorously assessing the utility of exclusion diets, antibiotics and probiotics in these children.

Funder

Funder

Autism Speaks

Fiscal Year Funding

Fiscal Year Funding

150000

Current Award Period

Current Award Period

2013-2016

Strategic Plan Question

Strategic Plan Question

Question 2: How Can I Understand What Is Happening?

Strategic Plan Objective

Strategic Plan Objective

Green dot: Objective has greater than or equal to the recommended funding. 2SE. Launch three studies that target the underlying biological mechanisms of co-occurring conditions with autism, including seizures/epilepsy, sleep disorders, wandering/elopement behavior, and familial autoimmune disorders, by 2012. IACC Recommended Budget: $9,000,000 over 5 years.

Project Link

Project Link

Molecular analysis of gene-environment interactions in the intestines of children with autism (External web link)

Institution

Institution

Columbia University

State/Country

State/Country

New York

Project Number

Project Number

8093

Federal or Private?

Federal or Private?

Private

Received ARRA Funding?

Received ARRA Funding?

No

History/Related Projects

History/Related Projects

Molecular analysis of gene-environment interactions in the intestines of children with autism | 150000 | 2014 | 8093
Molecular analysis of gene-environment interactions in the intestines of children with autism | 150000 | 2015 | 8093

 
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