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Interagency Autism Coordinating Committee (IACC)
Autism Research Database
Office of Autism Research Coordination (OARC)
 
Project Element Element Description

Project Title

Project Title

Acamprosate in Youth with Autism Spectrum Disorders

Principal Investigator

Principal Investigator

Erickson, Craig

Description

Description

This project describes an attempt to develop the first effective drug treatment for the core social impairments of autism spectrum disorders (ASDs). The project takes a significant step forward towards improving the quality of life of persons with ASDs through the development of more effective medicines. The primary objective of this project is to conduct a clinical trial of acamprosate in youth with ASDs. Based on preliminary data, acamprosate may be a safe and effective treatment for the social impairments associated with ASDs. A 10-week short-term acamprosate treatment study will be conducted in 36 youth with ASD aged 5 to 17 years followed by a 16 week study extension for participants who respond well to acamprosate in the short-term study. In addition to assessing whether acamprosate use is associated with reduced social impairments, this study will also closely assess how the youth taking acamprosate tolerate the drug. In addition, this project will measure proteins in the blood following acamprosate treatment, a study that may provide a better understanding of the brain biology associated with ASDs. Finally, a novel eye tracking test will be used to assess whether treatment with acamprosate is associated with any changes in how children with ASDs visually assess faces. Findings from this project will be essential to the design of a future, larger, more definitive study of acamprosate in youth with ASD. Developing effective medication options for the core social impairment of ASDs will fill a clear area of unmet medical need thus enhancing the quality of life of persons impacted by ASDs.

Funder

Funder

Autism Speaks

Fiscal Year Funding

Fiscal Year Funding

149719

Current Award Period

Current Award Period

2013-2016

Strategic Plan Question

Strategic Plan Question

Question 4: Which Treatments And Interventions Will Help?

Strategic Plan Objective

Strategic Plan Objective

Yellow dot: Objective has some degree of funding, but less than the recommended amount. 4SF. Launch randomized controlled trials of interventions including biological signatures and other measures to predict response, and monitor quality of life and functional outcomes in each of the following groups: o Five trials in infants and toddlers by 2013. IACC Recommended Budget: $30,000,000 over 5 years. o Three trials in school-aged children and/or adolescents by 2013. IACC Recommended Budget: $18,000,000 over 5 years. o Three trials in adults by 2014. IACC Recommended Budget: $18,000,000 over 5 years.

Project Link

Project Link

Acamprosate in Youth with Autism Spectrum Disorders (External web link)

Institution

Institution

Cincinnati Childrens Hospital Medical Center

State/Country

State/Country

Ohio

Project Number

Project Number

8075

Federal or Private?

Federal or Private?

Private

Received ARRA Funding?

Received ARRA Funding?

No

History/Related Projects

History/Related Projects

Acamprosate in Youth with Autism Spectrum Disorders | 149415 | 2014 | 8075
Acamprosate in Youth with Autism Spectrum Disorders | 149972 | 2015 | 8075

 
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