Teresa M. Reyes, Ph.D., of the University of Pennsylvania, will study abnormal birth weight as a biomarker of an adverse in utero environment and potential risk factor for schizophrenia and autism spectrum disorders. Maternal diet is one factor that can affect the uterine environment resulting in offspring who are small for gestational age (SGA) or large for gestational age (LGA). Epidemiological evidence indicates that both SGA and LGA infants are at increased risk for autism, while SGA is a strong risk factor for schizophrenia. By feeding pregnant mice low protein or high fat diets, Dr. Reyes and her team have developed mouse models of in utero environments that result in SGA or LGA offspring. She will now examine the development of social and anxiety-related behaviors in the offspring. These mice may prove a relevant animal model for schizophrenia, autism spectrum disorders and/or anxiety disorders.