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Interagency Autism Coordinating Committee (IACC)
Autism Research Database
Office of Autism Research Coordination (OARC)
 
Project Element Element Description

Project Title

Project Title

Adverse prenatal environment and altered social and anxiety-related behaviors

Principal Investigator

Principal Investigator

Reyes, Teresa

Description

Description

Teresa M. Reyes, Ph.D., of the University of Pennsylvania, will study abnormal birth weight as a biomarker of an adverse in utero environment and potential risk factor for schizophrenia and autism spectrum disorders. Maternal diet is one factor that can affect the uterine environment resulting in offspring who are small for gestational age (SGA) or large for gestational age (LGA). Epidemiological evidence indicates that both SGA and LGA infants are at increased risk for autism, while SGA is a strong risk factor for schizophrenia. By feeding pregnant mice low protein or high fat diets, Dr. Reyes and her team have developed mouse models of in utero environments that result in SGA or LGA offspring. She will now examine the development of social and anxiety-related behaviors in the offspring. These mice may prove a relevant animal model for schizophrenia, autism spectrum disorders and/or anxiety disorders.

Funder

Funder

Brain & Behavior Research Foundation

Fiscal Year Funding

Fiscal Year Funding

15000

Current Award Period

Current Award Period

2010-2013

Strategic Plan Question

Strategic Plan Question

Question 4: Which Treatments And Interventions Will Help?

Strategic Plan Objective

Strategic Plan Objective

Yellow dot: Objective has some degree of funding, but less than the recommended amount. 4SB. Standardize and validate at least 20 model systems (e.g., cellular and/or animal) that replicate features of ASD and will allow identification of specific molecular targets or neural circuits amenable to existing or new interventions by 2012. IACC Recommended Budget: $75,000,000 over 5 years.

Project Link

Project Link

No link available.

Institution

Institution

University of Pennsylvania

State/Country

State/Country

Pennsylvania

Project Number

Project Number

Federal or Private?

Federal or Private?

Private

Received ARRA Funding?

Received ARRA Funding?

No

History/Related Projects

History/Related Projects

Adverse prenatal environment and altered social and anxiety-related behaviors | 0 | 2011 | N/A
Adverse prenatal environment and altered social and anxiety-related behaviors | 45000 | 2012 | N/A

 
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