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Interagency Autism Coordinating Committee (IACC)
Autism Research Database
Office of Autism Research Coordination (OARC)
 
Project Element Element Description

Project Title

Project Title

Using Growth Trajectories To Predict Distal Outcomes in Parent-Implemented Intervention for Toddlers

Principal Investigator

Principal Investigator

Guthrie, Whitney

Description

Description

Early intervention for toddlers with ASD is critical, given the potential for altering brain development and the increasing focus on early screening and diagnosis. Although several interventions exist, many approaches are time- and resource-intensive, limiting the feasibility of their use in community settings. Parent-implemented approaches are a promising way to achieve the necessary intensity without requiring intensive community resources. However, evidence for the long-term effectiveness of any treatment for toddlers is limited. In addition, not all children have benefited similarly from any treatment, indicating the need to focus on using child characteristics to predict who may be likeliest to benefit from a given intervention. This study will address these needs through a follow-up assessment at ages 5-7 of the 82 participants of an RCT of the Early Social Interaction (ESI) Project, a parent-implemented intervention from 18-36 months. The first aim of this study is to examine long-term outcomes, including commonly used outcome measures (i.e., ADOS, ADI-R, IQ) as well as measures of broader outcomes that affect child and family quality of life (i.e., academic functioning, language, and emotional/behavioral problems and comorbidities). Change from end of treatment to school-age outcome will be examined, as well as maintenance of the effect of earlier (i.e., 18 months) versus later (i.e., 27 months) intensive parent-implemented intervention. Given that most studies find that some, but not all, children show improvement during intervention, it is important to separately examine treatment “responders” and “non-responders”. Children will be classified into groups based on their development during intervention, allowing for examination of differences in child characteristics at the start of intervention between these groups. These results will help clinicians predict whether a child will benefit from parent-implemented intervention. Classification of children into treatment response groups will also allow for comparison of long-term outcomes across response groups, in order to determine if and how change during treatment impacts school-age outcomes. Expected results will lend support to the long-term effectiveness of an early intervention program that is feasible in community settings, and clarify which children experience the greatest improvement from the toddler to school-age years based on how they develop during treatment. - See more at: http://science.grants.autismspeaks.org/search/grants/using-growth-trajectories-predict-distal-outcomes-parent-implemented-intervention-tod#sthash.JrIXkfxA.dpuf

Funder

Funder

Autism Speaks

Fiscal Year Funding

Fiscal Year Funding

29500

Current Award Period

Current Award Period

2013-2015

Strategic Plan Question

Strategic Plan Question

Question 4: Which Treatments And Interventions Will Help?

Strategic Plan Objective

Strategic Plan Objective

Green dot: Objective has greater than or equal to the recommended funding. 4LD. Support at least five community-based studies that assess the effectiveness of interventions and services in broader community settings by 2015. Such studies may include comparative effectiveness research studies that assess the relative effectiveness of: o Different and/or combined medical, pharmacological, nutritional, behavioral, service-provision, and parent- or caregiver-implemented treatments; o Scalable early intervention programs for implementation in underserved, low-resource, and low-literacy populations; and o Studies of widely used community intervention models for which extensive published data are not available. Outcome measures should include assessment of potential harm as a result of autism treatments, as well as positive outcomes. IACC Recommended Budget: $37,500,000 over 5 years.

Project Link

Project Link

Using Growth Trajectories To Predict Distal Outcomes in Parent-Implemented Intervention for Toddlers (External web link)

Institution

Institution

Florida State University

State/Country

State/Country

Florida

Project Number

Project Number

8551

Federal or Private?

Federal or Private?

Private

Received ARRA Funding?

Received ARRA Funding?

No

History/Related Projects

History/Related Projects

Using Growth Trajectories To Predict Distal Outcomes in Parent-Implemented Intervention for Toddlers | 29500 | 2014 | 8551
Using Growth Trajectories To Predict Distal Outcomes in Parent-Implemented Intervention for Toddlers | 0 | 2015 | 8551

 
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