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Interagency Autism Coordinating Committee (IACC)
Autism Research Database
Office of Autism Research Coordination (OARC)
 
Project Element Element Description

Project Title

Project Title

The Role of Shank3 in Neocortex Versus Striatum and the Pathophysiology of Autism

Principal Investigator

Principal Investigator

Bey, Alexandra

Description

Description

There are currently very limited options for treating patients with autism spectrum disorders due to poor understanding of the way the core behavioral deficits occur. In part, this is because the brain regions controlling the abnormal behaviors are unknown. This study will use a mouse model of autism, which allows us to very precisely disrupt the function of specific brain regions, to examine which regions control each category of ASD behavioral deficits. This will inform the development of new treatments that target specific brain regions tailored to the behavioral profile of the individual.

Funder

Funder

Autism Science Foundation

Fiscal Year Funding

Fiscal Year Funding

25000

Current Award Period

Current Award Period

2013-2014

Strategic Plan Question

Strategic Plan Question

Question 2: How Can I Understand What Is Happening?

Strategic Plan Objective

Strategic Plan Objective

Green dot: Objective has greater than or equal to the recommended funding. 2SG. Support five studies that associate specific genotypes with functional or structural phenotypes, including behavioral and medical phenotypes (e.g., nonverbal individuals with ASD and those with cognitive impairments) by 2015. IACC Recommended Budget: $22,600,000 over 5 years.

Project Link

Project Link

The Role of Shank3 in Neocortex Versus Striatum and the Pathophysiology of Autism (External web link)

Institution

Institution

Duke University

State/Country

State/Country

North Carolina

Project Number

Project Number

n/a

Federal or Private?

Federal or Private?

Private

Received ARRA Funding?

Received ARRA Funding?

No

History/Related Projects

History/Related Projects

The Role of Shank3 in Neocortex Versus Striatum and the Pathophysiology of Autism | 0 | 2014 |
The role of Shank3 in neocortex versus striatum and the pathophysiology of autism | 25000 | 2014 |
The role of Shank3 in neocortex versus striatum and the pathophysiology of autism | 0 | 2015 |

 
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