Skip to content
Interagency Autism Coordinating Committee (IACC)
Autism Research Database
Office of Autism Research Coordination (OARC)
 
Project Element Element Description

Project Title

Project Title

Paternal age and epigenetic mechanisms in psychiatric disease

Principal Investigator

Principal Investigator

Milekic, Maria H.

Description

Description

Maria H. Milekic, Ph.D., of the Research Foundation for Mental Hygiene, New York State Psychiatric Institute/Columbia University, will investigate a possible mechanism to explain findings that suggest that fathers over 40 years of age pose an increased risk for autism spectrum disorders in their children. The role of epigenetics may be an important factor. Epigenetics involves mechanisms such as DNA methylation in which the chemical methyl is added to a gene's DNA to change the way the gene is expressed. DNA methylation during production of new sperm is an active process, susceptible to errors that can be propagated to subsequent generations. To test whether the effects of paternal age on autism is due to epigenetic mechanisms, Dr. Milekic and her team have developed an animal model in which to compare methylation changes in the offspring of old and young fathers.

Funder

Funder

Brain & Behavior Research Foundation

Fiscal Year Funding

Fiscal Year Funding

15000

Current Award Period

Current Award Period

2011-2013

Strategic Plan Question

Strategic Plan Question

Question 3: What Caused This To Happen And Can This Be Prevented?

Strategic Plan Objective

Strategic Plan Objective

Green dot: Objective has greater than or equal to the recommended funding. 3SJ. Support at least three studies that focus on the role of epigenetics in the etiology of ASD, including studies that include assays to measure DNA methylations and histone modifications and those exploring how exposures may act on maternal or paternal genomes via epigenetic mechanisms to alter gene expression, by 2012. IACC Recommended Budget: $20,000,000 over 5 years.

Project Link

Project Link

No link available.

Institution

Institution

Research Foundation for Mental Hygiene, Inc/NYSPI

State/Country

State/Country

New York

Project Number

Project Number

Federal or Private?

Federal or Private?

Private

Received ARRA Funding?

Received ARRA Funding?

No

History/Related Projects

History/Related Projects

Paternal age and epigenetic mechanisms in psychiatric disease | 0 | 2011 | N/A
Paternal age and epigenetic mechanisms in psychiatric disease | 45000 | 2012 | N/A

 
Back to Top