The proposed collaborative research project is translational with both clinical and basic research components. The clinical component includes the recruitment of ~150 families from central Ohio in which one or more family members have a diagnosis of an autism spectrum disorder. Approximately 50% of the families will be enrolled in collaboration with developmental pediatricians at Wright-Patterson Air Force Base (WPAFB). Approved IRB protocols are currently active at both institutions [Nationwide Children’s Hospital and WPAFB]. Families enrolled in CORA will be able to participate in cutting edge molecular and genetic research studies. Direct benefits to families from WPAFB will include improved clinical care through the interaction of the WPAFB developmental pediatricians with an experienced clinical geneticist with expertise in the genetics of autism. In addition, families will receive a newsletter twice a year that will contain important information about autism, CORA, and ongoing research studies. Medically significant findings from the research will be shared with families who have indicated on the consent forms that they wish to receive this information.