Autism Research Database - Strategic Plan Objective Project Details | IACC

Project Element	Element Description
Project Title Project Title	Genomic influences on development and outcomes in Infants at risk of ASD
Principal Investigator Principal Investigator	Zwaigenbaum, Lonnie
Description Description	The High Risk Siblings Research Consortium was established in 2003 as a collaboration among NIH, Autism Speaks and researchers across the world who share a common mission of developing methods of early detection of ASD. The BSRC scientists have pooled their samples of high risk infant siblings of children with an autism diagnosis, who have been carefully monitored and assessed from infancy through early childhood. Research in this area has generated groundbreaking findings regarding risk factors, developmental trajectories and early behavioral and biological markers prior to diagnosis. The goal of this project is to extend our knowledge of early risk factors and biomarkers for ASD by collecting DNA on probands, siblings and parents.
Funder Funder	Autism Speaks
Funding Country Funding Country	United States
Fiscal Year Funding Fiscal Year Funding	$337,779
Current Award Period Current Award Period	2011-2014
Strategic Plan Question Strategic Plan Question	Question 3: What Caused This To Happen And Can This Be Prevented?
Strategic Plan Objective Strategic Plan Objective	Coordinate and implement the inclusion of approximately 20,000 subjects for genome-wide association studies, as well as a sample of 1,200 for sequencing studies to examine more than 50 candidate genes by 2011. Studies should investigate factors contributing to phenotypic variation across individuals that share an identified genetic variant and stratify subjects according to behavioral, cognitive, and clinical features.
Subcategory Subcategory	Genetic Risk Factors
Funder’s Project Link Funder’s Project Link	External Project Page
Institution Institution	University of Alberta
Institute Location Institute Location	Canada
Project Number Project Number	7880
Federal or Private Federal or Private	Private
History/Related Projects History/Related Projects	Genomic influences on development and outcomes in Infants at risk of ASD \| $337,779.00 \| 2011 \| 7880 Genomic influences on development and outcomes in Infants at risk of ASD \| $0.00 \| 2012 \| 7880 Genomic influences on development and outcomes in Infants at risk of ASD \| $0.00 \| 2014 \| 7880 Genomic influences on development and outcomes in Infants at risk of ASD \| $0.00 \| 2015 \| 7880

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