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Interagency Autism Coordinating Committee (IACC)
Autism Research Database
Office of Autism Research Coordination (OARC)
 
Project Element Element Description

Project Title

Project Title

Air pollution, MET genotype and ASD risk: GxE Interaction in the EMA Study

Principal Investigator

Principal Investigator

Croen, Lisa

Description

Description

Recent research has linked certain factors associated with air pollution to increased risk of ASD. This study will expand this finding by using prenatal blood obtained through the State of California to identify 1) genetic mutations of the MET receptor and whether these mutations affect the association, and 2) specific immune markers that may also contribute to risk. The researchers will map addresses of mothers to estimate the amount of air pollution they were exposed to while they were pregnant and early in the child’s life. Then, they will also look to see if genes of the mother and the child alter, or change, this risk. This research will study the MET gene, which has been linked with autism in many previous studies. There is evidence from animal data that the way MET works may be influenced by prenatal exposure to air pollution, supporting the biology of this interaction. However, MET also can affect the immune system. Studying how genes and the environment interact can provide important insights into the biology of ASD, making it possible for future research to test early identification or treatment methods. Understanding the role of the immune system in ASD through this interaction may also allow us to target specific environmental contaminants aiding the health of all people.

Funder

Funder

Autism Speaks

Fiscal Year Funding

Fiscal Year Funding

150000

Current Award Period

Current Award Period

2013-2015

Strategic Plan Question

Strategic Plan Question

Question 3: What Caused This To Happen And Can This Be Prevented?

Strategic Plan Objective

Strategic Plan Objective

Yellow dot: Objective has some degree of funding, but less than the recommended amount. 3SC. Initiate efforts to expand existing large case-control and other studies to enhance capabilities for targeted gene – environment research by 2011. IACC Recommended Budget: $27,800,000 over 5 years.

Project Link

Project Link

Air pollution, MET genotype and ASD risk: GxE Interaction in the EMA Study (External web link)

Institution

Institution

Kaiser Permanente

State/Country

State/Country

California

Project Number

Project Number

8463

Federal or Private?

Federal or Private?

Private

Received ARRA Funding?

Received ARRA Funding?

No

History/Related Projects

History/Related Projects

Air pollution, MET genotype and ASD risk: GxE Interaction in the EMA Study | 150000 | 2014 | 8463
Air pollution, MET genotype and ASD risk: GxE Interaction in the EMA Study | 0 | 2015 | 8463

 
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