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Interagency Autism Coordinating Committee (IACC)
Autism Research Database
Office of Autism Research Coordination (OARC)
 
Project Element Element Description

Project Title

Project Title

Prevalence and patterns of medical co-morbidity and healthcare use before ASD diagnoses in children

Principal Investigator

Principal Investigator

Croen, Lisa

Description

Description

Comprehensive electronic medical record data for a large, racially and ethnically diverse population of children born within the Kaiser Permanente (KP) Medical Care Program between 2000 and 2009 and who stayed members until at least age two will be collected from KP Northern California, Georgia, and the Northwest. Medical co-morbidities and health care utilization patterns experienced by children in these populations, who were diagnosed with an Autism Spectrum Disorder (ASD), will be compared with a non-ASD control population. The co-morbidities to be examined will include immune-related conditions (perinatal and pediatric infections, allergy, asthma, auto-immune conditions, and adverse reactions to vaccination), gastrointestinal symptoms, sleep problems, seizures, and other neurologic conditions, and metabolic disorders. Health care utilization patterns will include number of outpatient clinic visits (primary care, medical specialist, emergency care), vaccination history, and hospitalizations. The prevalence of co-morbidities and health care utilization in ASD cases and non-ASD controls will be described. In addition, longitudinal analyses to examine the period before ASD diagnosis will be conducted to determine if particular temporal patterns or health trajectories are associated with subsequent diagnosis with an ASD. Finally, the research team will examine if there is a temporal pattern in the occurrence or exacerbation of medical co-morbidities associated with regular childhood vaccinations, and whether this pattern is different for children with ASD compared to the non-ASD comparison group. Results from this study will help to fill important knowledge gaps in the understanding of the prevalence of medical co-morbidities and associated patterns of health care service utilization among this vulnerable population. This study may also identify certain health trajectories or co-morbidity patterns that are associated with later ASD diagnosis. That information could be used to improve the early identification of children at risk for ASD, thus maximizing the potential benefit of early intervention services on child development.

Funder

Funder

Autism Speaks

Fiscal Year Funding

Fiscal Year Funding

149999

Current Award Period

Current Award Period

2012-2014

Strategic Plan Question

Strategic Plan Question

Question 3: What Caused This To Happen And Can This Be Prevented?

Strategic Plan Objective

Strategic Plan Objective

Yellow dot: Objective has some degree of funding, but less than the recommended amount. 3SE. Support at least two studies to determine if there are subpopulations that are more susceptible to environmental exposures (e.g., immune challenges related to infections, vaccinations, or underlying autoimmune problems) by 2012. IACC Recommended Budget: $8,000,000 over 2 years.

Project Link

Project Link

Prevalence and patterns of medical co-morbidity and healthcare use before ASD diagnoses in children (External web link)

Institution

Institution

Kaiser Foundation Research Institute

State/Country

State/Country

California

Project Number

Project Number

7788

Federal or Private?

Federal or Private?

Private

Received ARRA Funding?

Received ARRA Funding?

No

History/Related Projects

History/Related Projects

Prevalence and patterns of medical co-morbidity and healthcare use before ASD diagnoses in children | 149999 | 2012 | 7788
Prevalence and patterns of medical co-morbidity and healthcare use before ASD diagnoses in children | 0 | 2014 | 7788

 
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