Skip to content
Interagency Autism Coordinating Committee (IACC)
Autism Research Database
Office of Autism Research Coordination (OARC)
 
Project Element Element Description

Project Title

Project Title

Parental Exposures to Occupational Asthmagens and Risk of Autism Spectrum Disorders

Principal Investigator

Principal Investigator

Singer, Alison

Description

Description

The causes of Autism Spectrum Disorders (ASDs) are not known, but there is evidence to suggest that environmental exposures may influence ASD risk. Immune activity in mothers during pregnancy has been suggested to be related to risk of ASD, and some occupational and environmental exposures can trigger an immune response. However, such exposures during pregnancy have not yet been studied in autism. The overall goal of this project is to examine the impact of occupational exposures to asthmagens (agents that can cause asthma) during pregnancy on ASD risk. Previous studies of environmental risk factors for ASDs have been limited by lack of data on exposures and lack of confirmation of ASD diagnoses. To overcome this, two comprehensive epidemiology studies will be used that have occupation information during pregnancy on mothers and fathers and also have in-depth diagnostic information, in addition to a large amount of other data on lifestyle, medical history, and genetics of parents and children: the Study to Explore Early Development (SEED), a national study of autism and the Early Autism Risk Longitudinal Investigation (EARLI) study, a pregnancy study that follows mothers through birth and children through the first 3 years of life. In aim 1, the association between parental exposures to occupational asthmagens and ASDs will be examined in the SEED study. In aim 2, the association between parental exposures to occupational asthmagens and behaviors at 6 and 12 months of age will be evaluated in the EARLI study. In aim 3, possible maternal genetic predisposition to these exposures will be considered. In aim 4, the association between a biological marker of immune response in mothers during pregnancy (prenatal serum IgE levels) and infant behaviors will be examined in EARLI. This final aim will serve as complementary evidence to support any detected occupational associations. This work will lead to a better understanding of the environmental conditions and immune responses that may influence risk of ASDs. Learning more about the causes of ASDs may lead to earlier detection, improved care, and possibly prevention. - See more at: http://science.grants.autismspeaks.org/search/grants/parental-exposures-occupational-asthmagens-and-risk-autism-spectrum-disorders#sthash.zhH8U2QE.dpuf

Funder

Funder

Autism Speaks

Fiscal Year Funding

Fiscal Year Funding

29500

Current Award Period

Current Award Period

2013-2015

Strategic Plan Question

Strategic Plan Question

Question 3: What Caused This To Happen And Can This Be Prevented?

Strategic Plan Objective

Strategic Plan Objective

Green dot: Objective has greater than or equal to the recommended funding. 3SH. Support at least three studies of special populations or use existing databases to inform our understanding of environmental risk factors for ASD in pregnancy and the early postnatal period by 2012. Such studies could include: o Comparisons of populations differing in geography, gender, ethnic background, exposure history (e.g., prematurity, maternal infection, nutritional deficiencies, toxins), and migration patterns; and o Comparisons of phenotype (e.g., cytokine profiles), in children with and without a history of autistic regression, adverse events following immunization (such as fever and seizures), and mitochondrial impairment. These studies may also include comparisons of phenotype between children with regressive ASD and their siblings. Emphasis on environmental factors that influence prenatal and early postnatal development is particularly of high priority. Epidemiological studies should pay special attention to include racially and ethnically diverse populations. IACC Recommended Budget: $12,000,000 over 5 years.

Project Link

Project Link

Parental Exposures to Occupational Asthmagens and Risk of Autism Spectrum Disorders (External web link)

Institution

Institution

Johns Hopkins University

State/Country

State/Country

Maryland

Project Number

Project Number

8576

Federal or Private?

Federal or Private?

Private

Received ARRA Funding?

Received ARRA Funding?

No

History/Related Projects

History/Related Projects

Parental Exposures to Occupational Asthmagens and Risk of Autism Spectrum Disorders | 29500 | 2014 | 8576
Parental Exposures to Occupational Asthmagens and Risk of Autism Spectrum Disorders | 0 | 2015 | 8576

 
Back to Top