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Interagency Autism Coordinating Committee (IACC)
Autism Research Database
Office of Autism Research Coordination (OARC)
 
Project Element Element Description

Project Title

Project Title

Prenatal Androgen in Meconium and Early Autism Spectrum Disorder Related Neurodevelopmental Outcomes

Principal Investigator

Principal Investigator

Park, Bo

Description

Description

In 2008, 1 in 88 children in the United States has been identified with autism spectrum disorders (ASDs) across all racial, ethnic, and socioeconomic groups. ASD is a life-long complex neuropsychiatric disease that affects the individual and the family with no known cause or cure. Furthermore, ASD occurs more commonly in males, with a male to female ratio of 4:1. Specific causal factors leading to the higher male prevalence in ASD remain unclear. This project will be based in the Early Autism Risk Longitudinal Investigation (EARLI), an enriched-risk autism pregnancy cohort collecting data on potential risk factors and biomarkers for ASDs during pre-, peri-, neonatal and early infancy periods. Enrolled subjects are mothers of a child with an ASD at the start of a subsequent pregnancy. Data from 175 mother-infant sibling pairs will be available for analysis. This project analyzes baby's first stool and cord blood for male hormone and also analyzes mother's pregnancy urine for common chemicals that mothers may be exposed to through the use of personal care products containing antimicrobials that are believed to possibly raise levels of male hormone. First, estimates of male hormone in cord blood and baby's first stool will be compared to investigate absolute individual and relative average gender differences based on measuring hormones in these two different samples. Second, associations will be estimated between male hormone level in cord and first stool sample and AOSI scores at 12 months (which measure a range of behaviors associated with autism risk). Third, prenatal male hormone levels will be examined to see if they are influenced by the amount of exposure to the chemical a mother has during pregnancy. The analysis will also consider a number of other factors in order to make sure differences in these do not account for the results (these include: sex, gestational age, pregnancy alcohol use, pregnancy smoking, birth order and mother's age). - See more at: http://science.grants.autismspeaks.org/search/grants/prenatal-androgen-meconium-and-early-autism-spectrum-disorder-related-neurodevelopmen#sthash.fR1R0m4H.dpuf

Funder

Funder

Autism Speaks

Fiscal Year Funding

Fiscal Year Funding

29423

Current Award Period

Current Award Period

2013-2015

Strategic Plan Question

Strategic Plan Question

Question 3: What Caused This To Happen And Can This Be Prevented?

Strategic Plan Objective

Strategic Plan Objective

Green dot: Objective has greater than or equal to the recommended funding. 3SH. Support at least three studies of special populations or use existing databases to inform our understanding of environmental risk factors for ASD in pregnancy and the early postnatal period by 2012. Such studies could include: o Comparisons of populations differing in geography, gender, ethnic background, exposure history (e.g., prematurity, maternal infection, nutritional deficiencies, toxins), and migration patterns; and o Comparisons of phenotype (e.g., cytokine profiles), in children with and without a history of autistic regression, adverse events following immunization (such as fever and seizures), and mitochondrial impairment. These studies may also include comparisons of phenotype between children with regressive ASD and their siblings. Emphasis on environmental factors that influence prenatal and early postnatal development is particularly of high priority. Epidemiological studies should pay special attention to include racially and ethnically diverse populations. IACC Recommended Budget: $12,000,000 over 5 years.

Project Link

Project Link

Prenatal Androgen in Meconium and Early Autism Spectrum Disorder Related Neurodevelopmental Outcomes (External web link)

Institution

Institution

Drexel University

State/Country

State/Country

Pennsylvania

Project Number

Project Number

8556

Federal or Private?

Federal or Private?

Private

Received ARRA Funding?

Received ARRA Funding?

No

History/Related Projects

History/Related Projects

Prenatal Androgen in Meconium and Early Autism Spectrum Disorder Related Neurodevelopmental Outcomes | 29409 | 2014 | 8556
Prenatal Androgen in Meconium and Early Autism Spectrum Disorder Related Neurodevelopmental Outcomes | 0 | 2015 | 8556

 
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