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Interagency Autism Coordinating Committee (IACC)
Autism Research Database
Office of Autism Research Coordination (OARC)
 
Project Element Element Description

Project Title

Project Title

Assessing sleep regulation, sleep-dependent memory consolidation, and sleep-dependent synaptic plasticity in mouse genetic models of schizophrenia and autism spectrum disorders

Principal Investigator

Principal Investigator

Aton, Sara J.

Description

Description

Sara J. Aton, Ph.D., of the University of Pennsylvania, will study the effects of sleep abnormalities on cognitive functions in schizophrenia and autism spectrum disorders. Sleep loss is known to have detrimental effects on cognitive function and on synaptic plasticity, the neural mechanism underlying learning and memory. Using mouse models, Dr. Aton will assess how sleep, sleep-mediated plasticity, and sleep-dependent memory consolidation are affected by genetic mutations associated with schizophrenia and autism. These studies will improve understanding of sleep-dependent consolidation mechanisms under normal and pathological conditions, and clarify the contribution of sleep deficits to the etiology of autism spectrum disorders and schizophrenia.

Funder

Funder

Brain & Behavior Research Foundation

Fiscal Year Funding

Fiscal Year Funding

32469

Current Award Period

Current Award Period

2011-2013

Strategic Plan Question

Strategic Plan Question

Question 2: How Can I Understand What Is Happening?

Strategic Plan Objective

Strategic Plan Objective

Green dot: Objective has greater than or equal to the recommended funding. 2SE. Launch three studies that target the underlying biological mechanisms of co-occurring conditions with autism, including seizures/epilepsy, sleep disorders, wandering/elopement behavior, and familial autoimmune disorders, by 2012. IACC Recommended Budget: $9,000,000 over 5 years.

Project Link

Project Link

No link available.

Institution

Institution

University of Pennsylvania

State/Country

State/Country

Pennsylvania

Project Number

Project Number

Federal or Private?

Federal or Private?

Private

Received ARRA Funding?

Received ARRA Funding?

No

History/Related Projects

History/Related Projects

Assessing sleep regulation, sleep-dependent memory consolidation, and sleep-dependent synaptic plasticity in mouse genetic models of schizophrenia and autism spectrum disorders | 0 | 2011 | N/A
Assessing sleep regulation, sleep-dependent memory consolidation, and sleep-dependent synaptic plasticity in mouse genetic models of schizophrenia and autism spectrum disorders | 45000 | 2012 | N/A

 
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