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Interagency Autism Coordinating Committee (IACC)
Autism Research Database
Office of Autism Research Coordination (OARC)
 
Project Element Element Description

Project Title

Project Title

Modeling gut microbial ecology and metabolism in autism using an innovative ex vivo approach

Principal Investigator

Principal Investigator

Allen-Vercoe, Emma

Description

Description

The hypothesis is that microbial secreted components of ASD-associated, but not healthy-associated gut microbiota ecosystems impart deleterious effects on colonocytes consistent with the gut pathology reported in autism. The specific aims are: 1) Screening of fecal water extracted from stool samples from 20 ASD and 20 control children for metabolites with proinflammatory effects on human colonocytes in vitro; 2) Derivation and characterization of chemostat-supported gut microbial communities from healthy and ASD subjects selected from the Aim 1; 3) Analysis of biological effects of secreted chemostat ecosystem products on human colonocytes in vitro.

Funder

Funder

Department of Defense - Army

Fiscal Year Funding

Fiscal Year Funding

0

Current Award Period

Current Award Period

2013-2015

Strategic Plan Question

Strategic Plan Question

Question 3: What Caused This To Happen And Can This Be Prevented?

Strategic Plan Objective

Strategic Plan Objective

Green dot: Objective has greater than or equal to the recommended funding. 3SI. Support at least two studies that examine potential differences in the microbiome of individuals with ASD versus comparison groups by 2012. IACC Recommended Budget: $1,000,000 over 2 years.

Project Link

Project Link

Modeling gut microbial ecology and metabolism in autism using an innovative ex vivo approach (External web link)

Institution

Institution

University of Guelph

State/Country

State/Country

Canada

Project Number

Project Number

AR120241

Federal or Private?

Federal or Private?

Federal

Received ARRA Funding?

Received ARRA Funding?

No

History/Related Projects

History/Related Projects

Modeling Gut Microbial Ecology and Metabolism in Autism Using an Innovative Ex Vivo Approach | 0 | 2014 | 2013-9
Modeling Gut Microbial Ecology and Metabolism in Autism Using an Innovative Ex Vivo Approach | 22441 | 2013 | 2013-9
Modeling gut microbial ecology and metabolism in autism using an innovative ex vivo approach | 122626 | 2012 | AR120241
Modeling gut microbial ecology and metabolism in autism using an innovative ex vivo approach | 0 | 2014 | AR120241
Modeling gut microbial ecology and metabolism in autism using an innovative ex vivo approach | 0 | 2015 | AR120241

 
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