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Interagency Autism Coordinating Committee (IACC)
Autism Research Database
Office of Autism Research Coordination (OARC)
 
Project Element Element Description

Project Title

Project Title

Evaluating the Functional Impact of Epigenetic Control Related Genes Mutated in both Schizophrenia and Autism

Principal Investigator

Principal Investigator

Xu, Bin

Description

Description

Bin Xu, Ph.D., Columbia University, will clarify the functional impact of three genes involved in epigenetic regulation that are mutated in both schizophrenia and autism spectrum disorder. Epigenetics refers to environmental factors that affect gene expression without altering the underlying DNA sequence. Using mouse models, Dr. Xu will study their temporal and spatial expression pattern, identify target genes and evaluate the functional impact of altered activity of these genes on brain development.

Funder

Funder

Brain & Behavior Research Foundation

Fiscal Year Funding

Fiscal Year Funding

0

Current Award Period

Current Award Period

2014-2016

Strategic Plan Question

Strategic Plan Question

Question 3: What Caused This To Happen And Can This Be Prevented?

Strategic Plan Objective

Strategic Plan Objective

Green dot: Objective has greater than or equal to the recommended funding. 3SJ. Support at least three studies that focus on the role of epigenetics in the etiology of ASD, including studies that include assays to measure DNA methylations and histone modifications and those exploring how exposures may act on maternal or paternal genomes via epigenetic mechanisms to alter gene expression, by 2012. IACC Recommended Budget: $20,000,000 over 5 years.

Project Link

Project Link

No link available.

Institution

Institution

Columbia University

State/Country

State/Country

New York

Project Number

Project Number

Federal or Private?

Federal or Private?

Private

Received ARRA Funding?

Received ARRA Funding?

No

History/Related Projects

History/Related Projects

Evaluating the Functional Impact of Epigenetic Control Related Genes Mutated in both Schizophrenia and Autism | 30000 | 2015 |
Evaluating the Functional Impact of Epigenetic Control Related Genes Mutated in both Schizophrenia and Autism | 30000 | 2014 |

 
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