Skip to content
Interagency Autism Coordinating Committee (IACC)
Autism Research Database
Office of Autism Research Coordination (OARC)
 
Project Element Element Description

Project Title

Project Title

Dissecting expression regulation of an autism GWAS hit

Principal Investigator

Principal Investigator

Weiss, Lauren A.

Description

Description

Lauren A. Weiss, Ph.D., of the University of California, San Francisco, will apply an innovative approach to translating data from genome-wide association studies (GWAS) likely to be relevant to autism and other neuropsychiatric diseases. One of the results, near a gene implicated in autism, suggests a complex regulatory network. Dr. Weiss aims to verify this by conducting experiments to manipulate expression of regulator genes and measure resulting changes in expression of the GWAS-implicated gene. To validate the gene's relevance to autism she will obtain patient (and family-based control) cell lines from individuals with identified genetic variants affecting putative regulator genes and expression of the affected gene. The hope is that this research could illuminate a novel pathway important in the pathogenesis of autism to a biological pathway unifying many genetically independent variants.

Funder

Funder

Brain & Behavior Research Foundation

Fiscal Year Funding

Fiscal Year Funding

15000

Current Award Period

Current Award Period

2011-2013

Strategic Plan Question

Strategic Plan Question

Question 3: What Caused This To Happen And Can This Be Prevented?

Strategic Plan Objective

Strategic Plan Objective

Green dot: Objective has greater than or equal to the recommended funding. 3LB. Identify genetic risk factors in at least 50% of people with ASD by 2014. IACC Recommended Budget: $33,900,000 over 6 years.

Project Link

Project Link

No link available.

Institution

Institution

University of California, San Francisco

State/Country

State/Country

California

Project Number

Project Number

Federal or Private?

Federal or Private?

Private

Received ARRA Funding?

Received ARRA Funding?

No

History/Related Projects

History/Related Projects

Dissecting expression regulation of an autism GWAS hit | 15000 | 2011 | N/A
Dissecting expression regulation of an autism GWAS hit | 30000 | 2012 | N/A

 
Back to Top