Lauren A. Weiss, Ph.D., of the University of California, San Francisco, will apply an innovative approach to translating data from genome-wide association studies (GWAS) likely to be relevant to autism and other neuropsychiatric diseases. One of the results, near a gene implicated in autism, suggests a complex regulatory network. Dr. Weiss aims to verify this by conducting experiments to manipulate expression of regulator genes and measure resulting changes in expression of the GWAS-implicated gene. To validate the gene's relevance to autism she will obtain patient (and family-based control) cell lines from individuals with identified genetic variants affecting putative regulator genes and expression of the affected gene. The hope is that this research could illuminate a novel pathway important in the pathogenesis of autism to a biological pathway unifying many genetically independent variants.