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Interagency Autism Coordinating Committee (IACC)
Autism Research Database
Office of Autism Research Coordination (OARC)
 
Project Element Element Description

Project Title

Project Title

Identifying Biomarkers of GI Morbidity in ASD: Linking Multi-omics and Human Behavior

Principal Investigator

Principal Investigator

Luna, Ruth Ann

Description

Description

The underlying biology of Autism Spectrum Disorders (ASD) may contribute significantly towards disease comorbidity. Gastrointestinal symptoms represent an important comorbidity in children with ASD and may also contribute directly towards their problem behaviors. Gastrointestinal symptoms often pose a dilemma to care providers because the presentation and cause in this population is ill defined and especially difficult to detect in children with limited verbal communication. This multi-site collaborative project is focused on identifying stool based biomarkers of gastrointestinal symptoms in children with ASD. This effort is based upon innovative findings that certain disease biomarkers are evident across a spectrum of gastrointestinal symptoms while absent in healthy individuals. Behavioral characterization of participants with ASD will allow evaluation of associations between specific behavioral traits, gastrointestinal disease profiles, and multi-omic (microbiome and metabolome) stool signatures. The ultimate goal of this project is to correlate stool biomarkers with behavioral traits in individuals with ASD and functional gastrointestinal disorders to help improve in the diagnosis of symptoms in children with ASD. Identification of correlates between clinical metadata and functional alterations in the microbiome may rapidly justify microbial manipulation as early therapy in children newly diagnosed with ASD.

Funder

Funder

Autism Speaks

Fiscal Year Funding

Fiscal Year Funding

238997

Current Award Period

Current Award Period

2014-2017

Strategic Plan Question

Strategic Plan Question

Question 3: What Caused This To Happen And Can This Be Prevented?

Strategic Plan Objective

Strategic Plan Objective

Green dot: Objective has greater than or equal to the recommended funding. 3SI. Support at least two studies that examine potential differences in the microbiome of individuals with ASD versus comparison groups by 2012. IACC Recommended Budget: $1,000,000 over 2 years.

Project Link

Project Link

Identifying Biomarkers of GI Morbidity in ASD: Linking Multi-omics and Human Behavior (External web link)

Institution

Institution

Baylor College of Medicine

State/Country

State/Country

Texas

Project Number

Project Number

9455

Federal or Private?

Federal or Private?

Private

Received ARRA Funding?

Received ARRA Funding?

No

History/Related Projects

History/Related Projects

Identifying Biomarkers of GI Morbidity in ASD: Linking Multi-omics and Human Behavior | 0 | 2015 | 9455

 
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