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Interagency Autism Coordinating Committee (IACC)
Autism Research Database
Office of Autism Research Coordination (OARC)
 
Project Element Element Description

Project Title

Project Title

Autism, GI symptoms and the enteric microbiota

Principal Investigator

Principal Investigator

Li, Ellen

Description

Description

A major challenge in addressing the relationship between autism spectrum disorders and gastrointestinal symptoms is that the tools used to assess the symptoms in children with autism differ from the ROME III questionnaire typically used to assess similar symptoms in other children. Ellen Li and her colleagues at the State University of New York at Stony Brook are aiming to characterize fecal microbiota and gastrointestinal symptoms in roughly 300 children with autism and their unaffected siblings within the Simons Simplex Collection (SSC). The SSC is a rigorously characterized set of genetic, anatomic and behavioral data drawn from 2,700 families that include one child with autism and unaffected parents and siblings. Li and her team propose to use the same questionnaires, including the ROME III, for both affected and unaffected siblings. They plan to analyze results from the fecal bacteria DNA analysis (using 16S rRNA gene sequencing) in conjunction with data concerning autism symptoms and gastrointestinal problems. Li’s group aims to determine whether individuals with autism show an increased prevalence of gastrointestinal complaints compared with their unaffected siblings and, if so, whether changes in the fecal microbial composition are associated with these complaints. The researchers plan to link these data with existing genetic data from SSC families. They plan to add the results obtained from this study, including the clinical and 16S rRNA sequence data, to the SSC database so that they can be made available to other investigators.

Funder

Funder

Simons Foundation

Fiscal Year Funding

Fiscal Year Funding

263666

Current Award Period

Current Award Period

2012-2015

Strategic Plan Question

Strategic Plan Question

Question 3: What Caused This To Happen And Can This Be Prevented?

Strategic Plan Objective

Strategic Plan Objective

Green dot: Objective has greater than or equal to the recommended funding. 3SI. Support at least two studies that examine potential differences in the microbiome of individuals with ASD versus comparison groups by 2012. IACC Recommended Budget: $1,000,000 over 2 years.

Project Link

Project Link

Autism, GI symptoms and the enteric microbiota (External web link)

Institution

Institution

The Research Foundation of the State University of New York

State/Country

State/Country

New York

Project Number

Project Number

239729

Federal or Private?

Federal or Private?

Private

Received ARRA Funding?

Received ARRA Funding?

No

History/Related Projects

History/Related Projects

Autism, GI symptoms and the enteric microbiota | 87642 | 2012 | 239729
Autism, GI symptoms and the enteric microbiota | 0 | 2015 | 239729
Autism, GI symptoms and the enteric microbiota | 350814 | 2013 | 239729

 
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