Improved understanding of the brain basis of social motivation in autism spectrum disorder (ASD) is needed to develop scientifically-informed treatments. Although joint attention is a key focus of interventions, the passive nature of most neuroscience research has offered little direct insight into activity in reward systems during interactions with a social partne0r. This project combines eye-tracking and electrophysiology to study joint attention in a simulated face-to-face interaction. This paradigm will allow us, for the first time, to identify biological markers of reward anticipation in the context of shared attention. To investigate the responsiveness of these markers to intervention, we have developed game-based paradigms designed to shape pro-social patterns of gaze. We will use these paradigms after administration of oxytocin versus placebo to test the hypothesis that administration of oxytocin facilitates social learning. This innovative research aims to shed light on the biological basis of self-motivated social behavior.