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Interagency Autism Coordinating Committee (IACC)
Autism Research Database
Office of Autism Research Coordination (OARC)
 
Project Element Element Description

Project Title

Project Title

Response Heterogeneity to GI Treatment, Autism Symptom and Improved Oxidative Stress

Principal Investigator

Principal Investigator

Levitt, Pat

Description

Description

For children with autism spectrum disorder (ASD) and functional constipation (FC), their major gastrointestinal disturbance, there is a major knowledge gap in determining: 1) how different children respond to FC treatment; 2) specific ASD symptoms that are most responsive and stably improved when FC is treated; and 3) oxidative stress implications of ASD-FC co-morbidities and the ability to improve disrupted biological status. Children’s Hospital Los Angeles and the Center for Autism and Neurodevelopmental Disorders in Orange County will work together on the largest prospective study to date, evaluating 120 children with ASD with FC. Baseline medical and behavioral evaluations are performed, with follow-up visits at 3, 6 and 12 months for monitoring FC treatment effectiveness, measuring changes in ASD-related symptoms and determining pathophysiological status using the gold-standard biomarker for oxidative stress, F2 alpha Isoprostane, which is increased dramatically in children with ASD and FC and is a highly sensitive measure of improved pathophysiology state. This project will bring much needed insight for determining response heterogeneity to FC treatment, relation to pathophysiological disturbances, and the development of scalable strategies for predicting, at diagnosis, ASD symptoms that will be most amendable to improvement for each child

Funder

Funder

Autism Speaks

Fiscal Year Funding

Fiscal Year Funding

144971

Current Award Period

Current Award Period

2014-2017

Strategic Plan Question

Strategic Plan Question

Question 4: Which Treatments And Interventions Will Help?

Strategic Plan Objective

Strategic Plan Objective

Yellow dot: Objective has some degree of funding, but less than the recommended amount. 4LC. Conduct at least one study to evaluate the safety and effectiveness of medications commonly used in the treatment of co-occurring conditions or specific behavioral issues in people with ASD by 2015. IACC Recommended Budget: $10,000,000 over 5 years.

Project Link

Project Link

Response Heterogeneity to GI Treatment, Autism Symptom and Improved Oxidative Stress (External web link)

Institution

Institution

Children's Hospital Los Angeles

State/Country

State/Country

California

Project Number

Project Number

9411

Federal or Private?

Federal or Private?

Private

Received ARRA Funding?

Received ARRA Funding?

No

History/Related Projects

History/Related Projects

Response Heterogeneity to GI Treatment, Autism Symptom and Improved Oxidative Stress | 0 | 2015 | 9411

 
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