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Interagency Autism Coordinating Committee (IACC)
Autism Research Database
Office of Autism Research Coordination (OARC)
 
Project Element Element Description

Project Title

Project Title

Development of accelerated diffusion and functional MRI scans with real-time motion tracking for children with autism

Principal Investigator

Principal Investigator

Manoach, Dara

Description

Description

Converging lines of evidence support the view that autism is a disorder of brain connectivity in which abnormal brain structure and reduced coordination of activity across brain regions give rise to core features. The findings of functional connectivity MRI (fcMRI) and diffusion tensor imaging (DTI) studies of the brain are major sources of evidence for this theory. Although these techniques can illuminate brain connectivity in vivo, they are highly sensitive to head motion. Recent studies demonstrate that head motion can give rise to the patterns of abnormal connectivity that have been reported in children with autism. Thus, prior findings of brain connectivity abnormalities in autism may instead reflect motion artifact, and future studies must overcome this problem to be valid reflections of brain connectivity in autism. We propose to develop functional and diffusion MRI as a valid research tools for children with autism, without requiring sedation or anesthesia, by incorporating millisecond level motion detection and correction into faster pulse sequences, and developing an optimized data analysis pipeline. This will ameliorate a major source of artifact and speed the scanning process, thereby maximizing the chance of successful scans. These tools will benefit current and future studies of children with autism.

Funder

Funder

Simons Foundation

Fiscal Year Funding

Fiscal Year Funding

96553

Current Award Period

Current Award Period

2013-2015

Strategic Plan Question

Strategic Plan Question

Question 1: When Should I Be Concerned?

Strategic Plan Objective

Strategic Plan Objective

Yellow dot: Objective has some degree of funding, but less than the recommended amount. 1LB. Develop at least five measures of behavioral and/or biological heterogeneity in children or adults with ASD, beyond variation in intellectual disability, that clearly relate to etiology and risk, treatment response and/or outcome by 2015. IACC Recommended Budget: $71,100,000 over 5 years.

Project Link

Project Link

Development of accelerated diffusion and functional MRI scans with real-time motion tracking for children with autism (External web link)

Institution

Institution

Massachusetts General Hospital

State/Country

State/Country

Massachusetts

Project Number

Project Number

321693

Federal or Private?

Federal or Private?

Private

Received ARRA Funding?

Received ARRA Funding?

No

History/Related Projects

History/Related Projects

Development of accelerated diffusion and functional MRI scans with real-time motion tracking for children with autism | 0 | 2013 | 321693
Development of accelerated diffusion and functional MRI scans with real-time motion tracking for children with autism | 96533 | 2015 | 321693

 
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