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Interagency Autism Coordinating Committee (IACC)
Autism Research Database
Office of Autism Research Coordination (OARC)
 
Project Element Element Description

Project Title

Project Title

Simons Simplex Collection support grant

Principal Investigator

Principal Investigator

Bernier, Raphael

Description

Description

The Simons Simplex Collection (SSC) is a unique, rigorously characterized sample of 2,700 families, designed to enrich the discovery of rare de novo events in autism spectrum disorders. Thirteen sites in North America recruited families who have only one child, between 4 and 18 years of age, with an autism spectrum disorder, and unaffected siblings and unaffected biological parents. Individuals with fragile X syndrome, Down syndrome, prematurity, neonatal complications and families with a history of psychiatric disorders are excluded. A detailed medical history was collected and extensive efforts and protocols ensured reliability in administration and scoring of the numerous assessments. Blood samples from all family members were sent to the Rutgers Cell and DNA Repository, genomic DNA was extracted and lymphoblastoid cell lines established and stored. Biospecimens, phenotypic and genotypic data are available to approved researchers via SFARI Base. More than 80 investigators have studies underway which have so far led to nine publications. A new partnership with the Interactive Autism Network (IAN) has created the SSC@IAN, to allow coordination of follow-up studies and to maintain a community of SSC families.

Funder

Funder

Simons Foundation

Fiscal Year Funding

Fiscal Year Funding

10000

Current Award Period

Current Award Period

2012-2017

Strategic Plan Question

Strategic Plan Question

Question 3: What Caused This To Happen And Can This Be Prevented?

Strategic Plan Objective

Strategic Plan Objective

Green dot: Objective has greater than or equal to the recommended funding. 3LB. Identify genetic risk factors in at least 50% of people with ASD by 2014. IACC Recommended Budget: $33,900,000 over 6 years.

Project Link

Project Link

Simons Simplex Collection support grant (External web link)

Institution

Institution

University of Washington

State/Country

State/Country

Washington

Project Number

Project Number

SSCSG-10

Federal or Private?

Federal or Private?

Private

Received ARRA Funding?

Received ARRA Funding?

No

History/Related Projects

History/Related Projects

Simons Simplex Collection support grant | 29752 | 2012 | SSCSG-10
Simons Simplex Collection support grant | 30000 | 2012 | SSCSG-7
Simons Simplex Collection support grant | 30000 | 2012 | SSCSG-9
Simons Simplex Collection support grant | 30000 | 2012 | SSCSG-12
Simons Simplex Collection support grant | 34200 | 2012 | SSCSG-8
Simons Simplex Collection support grant | 30040 | 2012 | SSCSG-3
Simons Simplex Collection support grant | 30000 | 2012 | SSCSG-15
Simons Simplex Collection support grant | 1430 | 2012 | SSCSG-1
Simons Simplex Collection support grant | 30000 | 2012 | SSCSG-4
Simons Simplex Collection support grant | 30000 | 2012 | SSCSG-6
Simons Simplex Collection support grant | 30000 | 2012 | SSCSG-13
Simons Simplex Collection support grant | 30682 | 2012 | SSCSG-2
Simons Simplex Collection support grant | 10000 | 2014 | SSCSG-9
Simons Simplex Collection support grant | 13200 | 2014 | SSCSG-6
Simons Simplex Collection support grant | 4134 | 2014 | SSCSG-7
Simons Simplex Collection support grant | 0 | 2014 | SSCSG-8
Simons Simplex Collection support grant | 10000 | 2014 | SSCSG-12
Simons Simplex Collection support grant | 10000 | 2014 | SSCSG-13
Simons Simplex Collection support grant | 10000 | 2014 | SSCSG-15
Simons Simplex Collection support grant | 0 | 2014 | SSCSG-2
Simons Simplex Collection support grant | 10000 | 2014 | SSCSG-3
Simons Simplex Collection support grant | 0 | 2014 | SSCSG-1
Simons Simplex Collection support grant | 0 | 2014 | SSCSG-4
Simons Simplex Collection support grant | 5983 | 2015 | SSCSG-15
Simons Simplex Collection support grant | 1831 | 2015 | SSCSG-8
Simons Simplex Collection support grant | 8800 | 2015 | SSCSG-2
Simons Simplex Collection support grant | 8912 | 2015 | SSCSG-9
Simons Simplex Collection support grant | 9159 | 2015 | SSCSG-7
Simons Simplex Collection support grant | 10000 | 2015 | SSCSG-10
Simons Simplex Collection support grant | 10000 | 2015 | SSCSG-3
Simons Simplex Collection support grant | 10000 | 2015 | SSCSG-13
Simons Simplex Collection support grant | 10000 | 2015 | SSCSG-12
Simons Simplex Collection support grant | 13200 | 2015 | SSCSG-6
Simons Simplex Collection support grant | 23171 | 2013 | SSCSG-4
Simons Simplex Collection support grant | 30000 | 2013 | SSCSG-6
Simons Simplex Collection support grant | 21675 | 2013 | SSCSG-1
Simons Simplex Collection support grant | 23645 | 2013 | SSCSG-7
Simons Simplex Collection support grant | 24484 | 2013 | SSCSG-10
Simons Simplex Collection support grant | 20991 | 2013 | SSCSG-8
Simons Simplex Collection support grant | 25704 | 2013 | SSCSG-12
Simons Simplex Collection support grant | 25735 | 2013 | SSCSG-9
Simons Simplex Collection support grant | 30000 | 2013 | SSCSG-13
Simons Simplex Collection support grant | 26824 | 2013 | SSCSG-15
Simons Simplex Collection support grant | 30000 | 2013 | SSCSG-2
Simons Simplex Collection support grant | 21268 | 2013 | SSCSG-3

 
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