Autism Research Database - Strategic Plan Objective Project Details | IACC

Project Element	Element Description
Project Title Project Title	Characterization of synaptic and neural circuitry dysfunction underlying ASD-like behaviors using a novel genetic mouse model
Principal Investigator Principal Investigator	Fu, Zhanyan
Description Description	Shank3 mutant mice are mouse models of ASD. Dr. Fu will test the hypothesis that Shank3 disruption has differential effects on certain glutamatergic synapses*. The goal is to generate a novel mouse model of ASD harboring the deleterious Shank3 mutations from human patients with ASD, in order to yield clinically relevant insights into the underlying mechanism of human ASD and related disorders.
Funder Funder	Brain & Behavior Research Foundation
Funding Country Funding Country	United States
Fiscal Year Funding Fiscal Year Funding	$15,000
Current Award Period Current Award Period	2014-2016
Strategic Plan Question Strategic Plan Question	Question 4: Which Treatments And Interventions Will Help?
Strategic Plan Objective Strategic Plan Objective	Standardize and validate at least 20 model systems (e.g., cellular and/or animal) that replicate features of ASD and will allow identification of specific molecular targets or neural circuits amenable to existing or new interventions by 2012.
Subcategory Subcategory	Model Systems/Therapeutic Targets
Funder’s Project Link Funder’s Project Link	No URL available.
Institution Institution	Duke University
Institute Location Institute Location	North Carolina
Project Number Project Number
Federal or Private Federal or Private	Private
History/Related Projects History/Related Projects	Characterization of synaptic and neural circuitry dysfunction underlying ASD-like behaviors using a novel genetic mouse model \| $0.00 \| 2012 \| N/A Characterization of synaptic and neural circuitry dysfunction underlying ASD-like behaviors using a novel genetic mouse model \| $0.00 \| 2013 \| Characterization of synaptic and neural circuitry dysfunction underlying ASD-like behaviors using a novel genetic mouse model \| $45,000.00 \| 2016 \| Characterization of synaptic and neural circuitry dysfunction underlying ASD-like behaviors using a novel genetic mouse model \| $0.00 \| 2015 \|

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