Autism Research Database - Strategic Plan Objective Project Details | IACC

Project Element	Element Description
Project Title Project Title	Testing brain overgrowth and synaptic models of autism using NPCs and neurons from patient-derived iPS cells
Principal Investigator Principal Investigator	Gage, Fred
Description Description	The goal of the study is to produce human cellular models of ASD. The PI will develop iPSCs from ASD patients and controls using cellular reprogramming, which are used to produce patient-derived neural progenitors (NPCs) and neurons. The cellular phenotypes, synaptogenesis will be studied in these NPCs and neurons. The specific aims are: 1) Functional characterization of NPC and neuron from ASD and controls for potential defects in proliferation, neurodevelopment and synaptogenesis; 2) Functional characterization of dysregulated pathways uncovered by gene expression from iPSC-derived NPC and neurons.
Funder Funder	Department of Defense - Army
Funding Country Funding Country	United States
Fiscal Year Funding Fiscal Year Funding	$0
Current Award Period Current Award Period	2013-2015
Strategic Plan Question Strategic Plan Question	Question 4: Which Treatments And Interventions Will Help?
Strategic Plan Objective Strategic Plan Objective	Standardize and validate at least 20 model systems (e.g., cellular and/or animal) that replicate features of ASD and will allow identification of specific molecular targets or neural circuits amenable to existing or new interventions by 2012.
Subcategory Subcategory	Model Systems/Therapeutic Targets
Funder’s Project Link Funder’s Project Link	External Project Page
Institution Institution	Salk Institute for Biological Studies
Institute Location Institute Location	California
Project Number Project Number	AR120131
Federal or Private Federal or Private	Federal
History/Related Projects History/Related Projects	Testing brain overgrowth and synaptic models of autism using NPCs and neurons from patient-derived iPS cells \| $315,375.00 \| 2012 \| AR120131P1 Testing brain overgrowth and synaptic models of autism using NPCs and neurons from patient-derived iPS cells \| $377,663.00 \| 2012 \| AR120131 Testing brain overgrowth and synaptic models of autism using NPCs and neurons from patient-derived iPS cells \| $0.00 \| 2013 \| AR120131 Testing brain overgrowth and synaptic models of autism using NPCs and neurons from patient-derived iPS cells \| $0.00 \| 2013 \| AR120131P1 Testing brain overgrowth and synaptic models of autism using NPCs and neurons from patient-derived iPS cells \| $0.00 \| 2015 \| AR120131 Testing brain overgrowth and synaptic models of autism using NPCs and neurons from patient-derived iPS cells \| $0.00 \| 2015 \| AR120131P1 Testing brain overgrowth and synaptic models of autism using NPCs and neurons from patient-derived iPS cells \| $0.00 \| 2014 \| AR120131P1

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