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Interagency Autism Coordinating Committee (IACC)
Autism Research Database
Office of Autism Research Coordination (OARC)
 
Project Element Element Description

Project Title

Project Title

A multidimensional database for the Simons Simplex Collection

Principal Investigator

Principal Investigator

Coppola, Giovanni

Description

Description

Genotyping, gene expression and genetic sequencing methods are generating large amounts of data that are potentially relevant to autism research. Collaborative efforts and a searchable, web-based repository would maximally harness this unprecedented load of information. Giovanni Coppola’s team at the University of California, Los Angeles, has created a database of about 800,000 DNA sequence variants from roughly 900 individuals in the Simons Simplex Collection (SSC), which includes data and biospecimens from 2,700 families affected by autism. The database of sequence variants is intended for browsing and data mining by autism researchers worldwide. Coppola’s next goal is to create and maintain a web-based server to host the SSC sequencing data and to support investigators in accessing it. The long-term goal of this work is to build a multidimensional platform that is able to host genetic (sequencing, genotyping), genomic (gene expression, epigenetic) and phenotypic (neuropsychological, anatomical, etc.) data, in order to enable web-based searches and collaborative analyses among research groups.

Funder

Funder

Simons Foundation

Fiscal Year Funding

Fiscal Year Funding

0

Current Award Period

Current Award Period

2012-2015

Strategic Plan Question

Strategic Plan Question

Question 7: What Other Infrastructure and Surveillance Needs Must Be Met?

Strategic Plan Objective

Strategic Plan Objective

7O. Not specific to Question 7 objectives

Project Link

Project Link

A multidimensional database for the Simons Simplex Collection (External web link)

Institution

Institution

University of California, Los Angeles

State/Country

State/Country

California

Project Number

Project Number

255998

Federal or Private?

Federal or Private?

Private

Received ARRA Funding?

Received ARRA Funding?

No

History/Related Projects

History/Related Projects

A multidimensional database for the Simons Simplex Collection | 88188 | 2012 | 255998
A multidimensional database for the Simons Simplex Collection | 149396 | 2013 | 255998
A multidimensional database for the Simons Simplex Collection | 61208 | 2014 | 255998

 
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