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Interagency Autism Coordinating Committee (IACC)
Autism Research Database
Office of Autism Research Coordination (OARC)
 
Project Element Element Description

Project Title

Project Title

Investigating Wnt signaling variants in mouse models of ASD

Principal Investigator

Principal Investigator

Cheyette, Benjamin

Description

Description

Benjamin Cheyette and his colleagues at the University of California, San Francisco have discovered several variations in the sequence of the DIXDC1 gene in individuals with autism, using DNA obtained from the Simons Simplex Collection. DIXDC1 encodes a protein involved in communication between neurons during development. This cell communication pathway, known as the WNT signaling pathway, has been implicated in autism by sequence findings involving other genes, such as CHD8. In preliminary experiments, Cheyette and his team found that sequence variants in DIXDC1 alter the efficiency of this protein in activating WNT signaling, and that disruption of DIXDC1 in cultured neurons affects the formation of synapses, or connections between neurons. They also found that disruption of this gene in mice affects behavior. Cheyette and his group aim to pursue these findings by testing whether the sequence variations found in individuals with autism similarly affect synapse development in cultured neurons, and whether mice with DIXDC1 disruption have similar developmental effects in their neurons.

Funder

Funder

Simons Foundation

Fiscal Year Funding

Fiscal Year Funding

0

Current Award Period

Current Award Period

2014-2015

Strategic Plan Question

Strategic Plan Question

Question 4: Which Treatments And Interventions Will Help?

Strategic Plan Objective

Strategic Plan Objective

Green dot: Objective has greater than or equal to the recommended funding. 4SB. Standardize and validate at least 20 model systems (e.g., cellular and/or animal) that replicate features of ASD and will allow identification of specific molecular targets or neural circuits amenable to existing or new interventions by 2012. IACC Recommended Budget: $75,000,000 over 5 years.

Project Link

Project Link

Investigating Wnt signaling variants in mouse models of ASD (External web link)

Institution

Institution

University of California, San Francisco

State/Country

State/Country

California

Project Number

Project Number

329269

Federal or Private?

Federal or Private?

Private

Received ARRA Funding?

Received ARRA Funding?

No

History/Related Projects

History/Related Projects

Investigating Wnt signaling variants in mouse models of ASD | 60000 | 2014 | 329269

 
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