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Interagency Autism Coordinating Committee (IACC)
Autism Research Database
Office of Autism Research Coordination (OARC)
 
Project Element Element Description

Project Title

Project Title

Simons Variation in Individuals Project (VIP) Functional Imaging Site

Principal Investigator

Principal Investigator

Sherr, Elliott

Description

Description

The Simons Foundation has funded five university-based medical centers to identify and study a large number of individuals (~200 families within two years) with a recurrent genetic variation (deletion or duplication of segment 16p11.2) that increases their risk of developing autism spectrum and other neuro­developmental disorders. The immediate goal is to identify medical, cognitive, neural and behavioral profiles shared by this genetically identified group. Families are recruited through web-based networks or referral by clinical genetic centers or testing laboratories. Extensive psychological and neurological testing and neuroimaging with a uniform protocol will take place at the collaborating medical centers. De-identified subject data and biospecimens will be available to qualified researchers worldwide. Careful analysis of genetically defined autism subtypes will allow detailed phenotypic comparisons within and between these groups to clarify genotype-phenotype correlations. Longer-term goals are to use these data to improve the quality of clinical care and to develop targeted interventions for individuals with autism.

Funder

Funder

Simons Foundation

Fiscal Year Funding

Fiscal Year Funding

385668

Current Award Period

Current Award Period

2010-2015

Strategic Plan Question

Strategic Plan Question

Question 2: How Can I Understand What Is Happening?

Strategic Plan Objective

Strategic Plan Objective

Green dot: Objective has greater than or equal to the recommended funding. 2SG. Support five studies that associate specific genotypes with functional or structural phenotypes, including behavioral and medical phenotypes (e.g., nonverbal individuals with ASD and those with cognitive impairments) by 2015. IACC Recommended Budget: $22,600,000 over 5 years.

Project Link

Project Link

Simons Variation in Individuals Project (VIP) Functional Imaging Site (External web link)

Institution

Institution

University of California, San Francisco

State/Country

State/Country

California

Project Number

Project Number

220843

Federal or Private?

Federal or Private?

Private

Received ARRA Funding?

Received ARRA Funding?

No

History/Related Projects

History/Related Projects

Simons Variation in Individuals Project (VIP) Functional Imaging Site | 303305 | 2011 | 216074
Simons Variation in Individuals Project (VIP) Functional Imaging Site | 1299083 | 2012 | 220843
Simons Variation in Individuals Project (VIP) Functional Imaging Site | 736449 | 2012 | 216074
Simons Variation in Individuals Project (VIP) Functional Imaging Site | 320196 | 2011 | 220843
Simons Variation in Individuals Project (VIP) Functional Imaging Site | 820597 | 2014 | 220843
Simons Variation in Individuals Project (VIP) Functional Imaging Site | 419819 | 2013 | 216074
Simons Variation in Individuals Project (VIP) Functional Imaging Site | 1142798 | 2013 | 220843

 
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