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Interagency Autism Coordinating Committee (IACC)
Autism Research Database
Office of Autism Research Coordination (OARC)
 
Project Element Element Description

Project Title

Project Title

Behavioral and neural underpinnings of learning in autism predict response to intervention

Principal Investigator

Principal Investigator

Jones, Rebecca

Description

Description

Early intervention is considered critical for the treatment of Autism Spectrum Disorders (ASD). Yet, recent reports suggest that there is significant variability in how children respond to classic behavioral intervention programs. Two distinct learning pedagogies are the foundation of most behavioral interventions: associative and reinforcement learning, but there is little understanding of whether there are differences in the behavior and neural systems of children with ASD in these learning domains. Novel paradigms appropriate for children as young as 2 years old will be developed to delineate fundamental learning skills as differentiated between developmentally delayed (DD) and children with ASD. A cohort of children with ASD will be treated with a modified version of the Early Social Interaction - Community Outreach (ESI-CO) intervention and after 3 and 6 months to determine if improvement, measured with ADOS-Change social communication scores, is predicted by abilities on the learning paradigms. A cohort of Typically Developing (TD), DD and children with ASD (4-6yrs) will be tested, in parallel, with neuroimaging to determine the preliminary neural underpinnings of these learning mechanisms. Resting state functional connectivity and diffusion tensor imaging (DTI) will be used to provide a comprehensive understanding of any changes which may be observed in learning related neural circuitry in ASD versus TD and DD. These studies will provide the foundation to examine learning in animal models of ASD. To understand the behavioral and neural basis of learning in ASD, a translational approach is utilized to create a novel tool to individualize interventions, measure the effectiveness of treatment and improve patient care and outcome. To accomplish these research objectives, mentoring will involve a unique multidisciplinary team in order to facilitate the development of novel instruments that will directly assess learning in ASD and provide training in the theoretical and methodological analyses for interpreting the three complementary measures of neuroimaging data. The training gained in this program of research would enable the fellow to pursue a career as an independent scientist in the field of the neuroscience of ASD.

Funder

Funder

Autism Speaks

Fiscal Year Funding

Fiscal Year Funding

0

Current Award Period

Current Award Period

2012-2015

Strategic Plan Question

Strategic Plan Question

Question 4: Which Treatments And Interventions Will Help?

Strategic Plan Objective

Strategic Plan Objective

Yellow dot: Objective has some degree of funding, but less than the recommended amount. 4SF. Launch randomized controlled trials of interventions including biological signatures and other measures to predict response, and monitor quality of life and functional outcomes in each of the following groups: o Five trials in infants and toddlers by 2013. IACC Recommended Budget: $30,000,000 over 5 years. o Three trials in school-aged children and/or adolescents by 2013. IACC Recommended Budget: $18,000,000 over 5 years. o Three trials in adults by 2014. IACC Recommended Budget: $18,000,000 over 5 years.

Project Link

Project Link

Behavioral and neural underpinnings of learning in autism predict response to intervention (External web link)

Institution

Institution

Weill Cornell Medical College

State/Country

State/Country

New York

Project Number

Project Number

7608

Federal or Private?

Federal or Private?

Private

Received ARRA Funding?

Received ARRA Funding?

No

History/Related Projects

History/Related Projects

Behavioral and neural underpinnings of learning in autism predict response to intervention | 48000 | 2012 | 7608
Behavioral and neural underpinnings of learning in autism predict response to intervention | 0 | 2014 | 7608
Behavioral and neural underpinnings of learning in autism predict response to intervention | 50000 | 2013 | 7608

 
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