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Interagency Autism Coordinating Committee (IACC)
Autism Research Database
Office of Autism Research Coordination (OARC)
 
Project Element Element Description

Project Title

Project Title

Preclinical Autism Consortium for Therapeutics (PACT)

Principal Investigator

Principal Investigator

Crawley, Jacqueline

Description

Description

This project represents a consortium of basic researchers with expertise in rodent models of autism spectrum disorders who seek to discover effective treatments for the core symptoms of autism. Mice and rats with genetic mutations associated with autism display abnormal social behaviors, reduced vocalizations, stereotyped circling, repetitive self-grooming, seizures, anxiety-like behaviors, and cognitive deficits. These symptoms in mice and rats will be used as preclinical assays to test potential drug treatments. Pharmacological interventions will be assessed for their ability to restore normal sociability and communication skills, to reduce repetitive behaviors, to lessen seizures and anxiety-like behaviors, to correct hypo- and hyper-responsivity to sensory stimuli, and to improve cognitive disabilities. The choice of pharmacological compounds will be based on knowledge about the genetic mutations associated with autism which act to impair synaptic connections between neurons in the brain. Compounds that reproducibly reduce symptoms in both mouse and rat models of autism will point the way to clinical trials for medications to improve the diagnostic and associated symptoms of autism. - See more at: http://science.grants.autismspeaks.org/search/grants/preclinical-autism-consortium-therapeutics-pact#sthash.9PTpYTk5.dpuf

Funder

Funder

Autism Speaks

Fiscal Year Funding

Fiscal Year Funding

0

Current Award Period

Current Award Period

2013-2015

Strategic Plan Question

Strategic Plan Question

Question 4: Which Treatments And Interventions Will Help?

Strategic Plan Objective

Strategic Plan Objective

Green dot: Objective has greater than or equal to the recommended funding. 4SB. Standardize and validate at least 20 model systems (e.g., cellular and/or animal) that replicate features of ASD and will allow identification of specific molecular targets or neural circuits amenable to existing or new interventions by 2012. IACC Recommended Budget: $75,000,000 over 5 years.

Project Link

Project Link

Preclinical Autism Consortium for Therapeutics (PACT) (External web link)

Institution

Institution

University of California, Davis

State/Country

State/Country

California

Project Number

Project Number

8703

Federal or Private?

Federal or Private?

Private

Received ARRA Funding?

Received ARRA Funding?

No

History/Related Projects

History/Related Projects

Preclinical Autism Consortium for Therapeutics (PACT) | 200894 | 2013 | 8703
Preclinical Autism Consortium for Therapeutics (PACT) | 389677 | 2014 | 8703
Preclinical Autism Consortium for Therapeutics (PACT) at Baylor College of Medicine | 98351 | 2013 | 8533
Preclinical Autism Consortium for Therapeutics (PACT)- Boston Children's Hospital | 0 | 2015 | 8702
Preclinical Autism Consortium for Therapeutics (PACT)- Boston Children's Hospital | 172009 | 2013 | 8702
Preclinical Autism Consortium for Therapeutics (PACT)- Boston Children's Hospital | 316301 | 2014 | 8702
Preclinical Autism Consortium for Therapeutics (PACT)-Boston Children's Hospital Site | 91174 | 2013 | 8535

 
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