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Interagency Autism Coordinating Committee (IACC)
Autism Research Database
Office of Autism Research Coordination (OARC)
 
Project Element Element Description

Project Title

Project Title

Rutgers, The State University of New Jersey

Principal Investigator

Principal Investigator

No PI Listed

Description

Description

The Rutgers University Cell and DNA Repository (RUCDR) coordinates the shipment, receipt, processing, and distribution of all the biospecimens in the Simons Simplex Collection. The RUCDR Communications Department assembles the mailing kits that are used by the collection sites to submit blood samples and coordinates the receipt of the samples, including logging them into a database with direct reporting to the SFARI database. The various labs at RUCDR then process the samples for creation of Epstein-Barr virus (EBV)-transformed cell lines to serve as a renewable resource for scientific investigation, as well as extraction of DNA and plasma for distribution to Simons Foundation-approved investigators. Each sample that is processed at the RUCDR undergoes extensive quality control and identity assessment, including SNP genotyping with an identity panel, fragile X testing to aid in curating the SSC for exclusion of participants with fragile X, and parentage testing to ensure that the pedigree relationships of each family are correct.

Funder

Funder

Simons Foundation

Fiscal Year Funding

Fiscal Year Funding

819581

Current Award Period

Current Award Period

2015

Strategic Plan Question

Strategic Plan Question

Question 7: What Other Infrastructure and Surveillance Needs Must Be Met?

Strategic Plan Objective

Strategic Plan Objective

Yellow dot: Objective has some degree of funding, but less than the recommended amount. 7D. Establish and maintain an international network of biobanks for the collection of brain tissue, fibroblasts for pluripotent stem cells, and other tissue or biological material, by acquisition sites that use standardized protocols for phenotyping, collection, and regulated distribution of limited samples by 2011. o This includes support for post-processing of tissue, such as genotyping, RNA expression profiling, and MRI. o Protocols should be put into place to expand the capacities of ongoing large-scale children's studies to collect and store additional biomaterials, including newborn bloodspots, promoting detection of biological signatures. o Support should also be provided to develop an international web-based digital brain atlas that would provide high-resolution 3-D images and quantitative anatomical data from tissue of patients with ASD and disease controls across the lifespan, which could serve as an online resource for quantitative morphological studies, by 2014. IACC Recommended Budget: $82,700,000 over 5 years.

Project Link

Project Link

Rutgers, The State University of New Jersey (External web link)

Institution

Institution

Rutgers University

State/Country

State/Country

New Jersey

Project Number

Project Number

Federal or Private?

Federal or Private?

Private

Received ARRA Funding?

Received ARRA Funding?

No

History/Related Projects

History/Related Projects

Rutgers, The State University of New Jersey | 4930840 | 2010 | n/a
Rutgers, The State University of New Jersey | 4729271 | 2009 | Project number unavailable
Rutgers, The State University of New Jersey | 5333663 | 2011 | N/A
Rutgers, The State University of New Jersey | 368041 | 2012 | N/A
Rutgers, The State University of New Jersey | 640635 | 2014 |
Rutgers, The State University of New Jersey | 1439734 | 2013 | N/A

 
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