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Interagency Autism Coordinating Committee (IACC)
Autism Research Database
Office of Autism Research Coordination (OARC)
 
Project Element Element Description

Project Title

Project Title

Modulation of neuronal cysteine uptake and redox status by morphine, gluten/casein-derived opiates and naltrexone

Principal Investigator

Principal Investigator

Deth, Richard

Description

Description

Using cultured human neuronal and glial cells, the project will investigate the dose-dependent ability of opiate receptor agonists and antagonists to affect excitatory amino acid transporter 3 (EAAT3)-mediated cysteine uptake. Results will provide a mechanistic link between the gluten-free, casein-free diet (GF/CF), low dose naltrexone (LDN), and the metabolic pathway whose dysfunction underlies autism.

Funder

Funder

Autism Research Institute

Fiscal Year Funding

Fiscal Year Funding

44000

Current Award Period

Current Award Period

na

Strategic Plan Question

Strategic Plan Question

Question 2: How Can I Understand What Is Happening?

Strategic Plan Objective

Strategic Plan Objective

Green dot: Objective has greater than or equal to the recommended funding. 2SA. Support at least four research projects to identify mechanisms of metabolic and/or immune system interactions with the central nervous system that may underlie the development of ASD during prenatal-postnatal life by 2010. IACC Funding Budget: $9,800,000 over 4 years.

Project Link

Project Link

Modulation of neuronal cysteine uptake and redox status by morphine, gluten/casein-derived opiates and naltrexone (External web link)

Institution

Institution

Northeastern University School of Pharmacy

State/Country

State/Country

Massachusetts

Project Number

Project Number

2009-5

Federal or Private?

Federal or Private?

Private

Received ARRA Funding?

Received ARRA Funding?

No

History/Related Projects

History/Related Projects

N/A

 
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