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Interagency Autism Coordinating Committee (IACC)
Autism Research Database
Office of Autism Research Coordination (OARC)
 
Project Element Element Description

Project Title

Project Title

Neuronal nicotinic receptor modulation in the treatment of autism: A pilot trial of mecamylamine

Principal Investigator

Principal Investigator

Arnold, L. Eugene

Description

Description

One consistently identified abnormality in autism is a reduction in one of the receptors (nicotinic) for the neurotransmitter acetylcholine. The proposed pilot trial aims to test the response of individuals with autism to agents that target this receptor type, thus changing acetylcholine signaling. There is one nicotinic agent that has been shown to be safe in other childhood-onset disorders. This agent will be pilot-tested in children with autism. Twenty children with autism spectrum disorder will receive the drug or placebo over 13 weeks in a controlled (placebo double-blind) trial. The outcome will be assessed by standard clinical rating scales which will measure a range of behavioral and communicative functions, including attention. Computerized testing will also be used to assess changes in attention objectively.

Funder

Funder

Autism Speaks

Fiscal Year Funding

Fiscal Year Funding

44917

Current Award Period

Current Award Period

na

Strategic Plan Question

Strategic Plan Question

Question 4: Which Treatments And Interventions Will Help?

Strategic Plan Objective

Strategic Plan Objective

Yellow dot: Objective has some degree of funding, but less than the recommended amount. 4LC. Conduct at least one study to evaluate the safety and effectiveness of medications commonly used in the treatment of co-occurring conditions or specific behavioral issues in people with ASD by 2015. IACC Recommended Budget: $10,000,000 over 5 years.

Project Link

Project Link

Neuronal nicotinic receptor modulation in the treatment of autism: A pilot trial of mecamylamine (External web link)

Institution

Institution

The Ohio State University

State/Country

State/Country

Ohio

Project Number

Project Number

2368

Federal or Private?

Federal or Private?

Private

Received ARRA Funding?

Received ARRA Funding?

No

History/Related Projects

History/Related Projects

Neuronal nicotinic receptor modulation in the treatment of autism: A pilot trial of mecamylamine | 0 | 2010 | 2368

 
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