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Interagency Autism Coordinating Committee (IACC)
Autism Research Database
Office of Autism Research Coordination (OARC)
 
Project Element Element Description

Project Title

Project Title

The role of SHANK3 in the etiology of autism spectrum disorder

Principal Investigator

Principal Investigator

Bangash, M.

Description

Description

Mutations in the SHANK3 gene have been implicated in a subset of patients with autism spectrum disorder (ASD) in a gene-dosage dependent manner. SHANK3, a putative scaffold molecule found at the post-synaptic density (PSD), binds multiple partners and has been termed the master scaffolding molecule of the PSD. One of the key interactors of SHANK3 is the Homer class of signaling and scaffold molecules. SHANK3 and Homer act in concert to regulate spine maturation. The study describes a novel Homer-dependent mechanism to stabilize SHANK3 at the PSD. Both genetic and pharmacological tools can modulate this pathway, thus having implications for ASD therapy. Finally, the study is making a novel mouse model of SHANK3 that mimics a reported deletion of the Homer-binding domain of SHANK3 in patients with ASD. This mouse model will be a useful tool to study the in vivo function of SHANK3. The study makes predictions on the stability of SHANK3 in this mouse model and proposes a repertoire of biochemical and behavioral tests to link its molecular model with ASD-like behavior.

Funder

Funder

Autism Speaks

Fiscal Year Funding

Fiscal Year Funding

28000

Current Award Period

Current Award Period

na

Strategic Plan Question

Strategic Plan Question

Question 4: Which Treatments And Interventions Will Help?

Strategic Plan Objective

Strategic Plan Objective

Green dot: Objective has greater than or equal to the recommended funding. 4SB. Standardize and validate at least 20 model systems (e.g., cellular and/or animal) that replicate features of ASD and will allow identification of specific molecular targets or neural circuits amenable to existing or new interventions by 2012. IACC Recommended Budget: $75,000,000 over 5 years.

Project Link

Project Link

The role of SHANK3 in the etiology of autism spectrum disorder (External web link)

Institution

Institution

Johns Hopkins University

State/Country

State/Country

Maryland

Project Number

Project Number

2561

Federal or Private?

Federal or Private?

Private

Received ARRA Funding?

Received ARRA Funding?

No

History/Related Projects

History/Related Projects

The role of SHANK3 in the etiology of autism spectrum disorder | 28000 | 2010 | 6313
The role of SHANK3 in the etiology of autism spectrum disorder | 0 | 2011 | 6313

 
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