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Interagency Autism Coordinating Committee (IACC)
Autism Research Database
Office of Autism Research Coordination (OARC)
 
Project Element Element Description

Project Title

Project Title

DNA methylation and other epigenetic studies of autism brain

Principal Investigator

Principal Investigator

Beaudet, Arthur

Description

Description

This study is looking for abnormal gene expression patterns in the brains of individuals with autism. One way that genes are turned off is through DNA methylation: an enzyme places a methyl group onto certain sequences of DNA, thus flagging those genes for silencing. Thus, by examining the methylation status of genes, one can tell whether the gene is turned off or not. Researchers will examine the methylation patterns of genes taken from post-mortem brain tissue of autistic individuals and compare them to tissue from controls. The primary tool for analysis will be DNA microarrays ("gene chips"), which allow a genome-wide scan.

Funder

Funder

Autism Speaks

Fiscal Year Funding

Fiscal Year Funding

0

Current Award Period

Current Award Period

na

Strategic Plan Question

Strategic Plan Question

Question 3: What Caused This To Happen And Can This Be Prevented?

Strategic Plan Objective

Strategic Plan Objective

3O. Not specific to Question 3 objectives

Project Link

Project Link

DNA methylation and other epigenetic studies of autism brain (External web link)

Institution

Institution

Baylor College of Medicine

State/Country

State/Country

Texas

Project Number

Project Number

2230

Federal or Private?

Federal or Private?

Private

Received ARRA Funding?

Received ARRA Funding?

No

History/Related Projects

History/Related Projects

DNA methylation and other epigenetic studies of autism brain | 43986 | 2010 | 2230
DNA methylation and other epigenetic studies of autism brain | 29000 | 2008 | 2230

 
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