The purpose of this National Research Service Award is to provide support to an individual for combined M.D./Ph.D. and other dual doctoral degree training. Researchers recently found that a single nucleotide polymorphism (SNP) in a region that regulates the transcription of the human MET gene (rs1858830 allele 'C') is strongly associated with ASD. This mutation reduces gene transcription, which effectively reduces the amount of the gene available to be turned into functional protein. The goals of this study include: 1) determining the transcriptional regulators of a functional variant in the human MET promoter that is associated with ASD vulnerability and 2) defining the mechanisms through which the mouse Met receptor tyrosine kinase influences forebrain development. Results from these studies will help to explain how dysregulation of MET may lead to altered brain development and increased ASD susceptibility.