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Interagency Autism Coordinating Committee (IACC)
Autism Research Database
Office of Autism Research Coordination (OARC)
 
Project Element Element Description

Project Title

Project Title

Regulation of MET expression in autism disorder and forebrain ontogeny

Principal Investigator

Principal Investigator

Bergman, Mica

Description

Description

The purpose of this National Research Service Award is to provide support to an individual for combined M.D./Ph.D. and other dual doctoral degree training. Researchers recently found that a single nucleotide polymorphism (SNP) in a region that regulates the transcription of the human MET gene (rs1858830 allele 'C') is strongly associated with ASD. This mutation reduces gene transcription, which effectively reduces the amount of the gene available to be turned into functional protein. The goals of this study include: 1) determining the transcriptional regulators of a functional variant in the human MET promoter that is associated with ASD vulnerability and 2) defining the mechanisms through which the mouse Met receptor tyrosine kinase influences forebrain development. Results from these studies will help to explain how dysregulation of MET may lead to altered brain development and increased ASD susceptibility.

Funder

Funder

National Institutes of Health

Fiscal Year Funding

Fiscal Year Funding

25800

Current Award Period

Current Award Period

na

Strategic Plan Question

Strategic Plan Question

Question 2: How Can I Understand What Is Happening?

Strategic Plan Objective

Strategic Plan Objective

Green dot: Objective has greater than or equal to the recommended funding. 2SG. Support five studies that associate specific genotypes with functional or structural phenotypes, including behavioral and medical phenotypes (e.g., nonverbal individuals with ASD and those with cognitive impairments) by 2015. IACC Recommended Budget: $22,600,000 over 5 years.

Project Link

Project Link

Regulation of MET expression in autism disorder and forebrain ontogeny (External web link)

Institution

Institution

Vanderbilt University

State/Country

State/Country

Tennessee

Project Number

Project Number

5F30MH083474-03

Federal or Private?

Federal or Private?

Federal

Received ARRA Funding?

Received ARRA Funding?

No

History/Related Projects

History/Related Projects

Regulation of MET expression in autism disorder and forebrain ontogeny | 25583 | 2008 | F30MH083474-02

 
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