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Interagency Autism Coordinating Committee (IACC)
Autism Research Database
Office of Autism Research Coordination (OARC)
 
Project Element Element Description

Project Title

Project Title

Olivocerebellar circuitry in autism

Principal Investigator

Principal Investigator

Blatt, Gene

Description

Description

Autism is a developmental disorder and affected individuals have alterations in brain function disrupting their ability to perform particular motor and cognitive tasks. The main long term objective of this project is to determine in one major affected brain region, the cerebellum, how synaptic connectivity is disturbed in autism. This post-mortem study will conduct quantitative measures of important synaptic proteins (i.e., glutamatergic transporters and receptors) and relate these measures to the subjects' scores from the Autism Diagnostic Interview-Revised (ADI-R) for reciprocal social interaction, communication, and stereotyped and repetitive motor behavior domains. Data from these studies will help identify core neural substrates that may underlie specific behavioral challenges in autistic individuals and should help guide geneticists in their search for possible candidate genes in the disorder, as well as contribute to understanding current pharmacotherapeutic treatments of autism and develop new treatments targeted to neural substrates.

Funder

Funder

National Institutes of Health

Fiscal Year Funding

Fiscal Year Funding

756843

Current Award Period

Current Award Period

na

Strategic Plan Question

Strategic Plan Question

Question 3: What Caused This To Happen And Can This Be Prevented?

Strategic Plan Objective

Strategic Plan Objective

3O. Not specific to Question 3 objectives

Project Link

Project Link

Olivocerebellar circuitry in autism (External web link)

Institution

Institution

Boston University Medical Campus

State/Country

State/Country

Massachusetts

Project Number

Project Number

2R01HD039459-05A1

Federal or Private?

Federal or Private?

Federal

Received ARRA Funding?

Received ARRA Funding?

Yes

History/Related Projects

History/Related Projects

Olivocerebellar circuitry in autism | 756917 | 2010 | 5R01HD039459-06

 
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