Skip to content
Interagency Autism Coordinating Committee (IACC)
Autism Research Database
Office of Autism Research Coordination (OARC)
 
Project Element Element Description

Project Title

Project Title

Pathway-based genetic studies of autism spectrum disorder

Principal Investigator

Principal Investigator

Bucan, Maja

Description

Description

Autism spectrum disorders have a strong genetic component, with an estimated heritability of greater than 90%, but many genes associated with autism have not yet been identified. In this study, the full spectrum of genetic variations associated with autism, both rare and common, will be analyzed in a gene function and pathway-based approach. Incorporating the known functions and interactions of the affected genes, Dr. Bucan and colleagues will identify the molecular functions and pathways that are enriched in this set of genes. Two types of genetic variation will be considered: single nucleotide polymorphisms, where one base pair of deoxyribonucleic acid (DNA) is mutated, and gene copy number variants, where multiple copies of genes are inserted into the genomic DNA.

Funder

Funder

Autism Speaks

Fiscal Year Funding

Fiscal Year Funding

60000

Current Award Period

Current Award Period

na

Strategic Plan Question

Strategic Plan Question

Question 3: What Caused This To Happen And Can This Be Prevented?

Strategic Plan Objective

Strategic Plan Objective

Green dot: Objective has greater than or equal to the recommended funding. 3LB. Identify genetic risk factors in at least 50% of people with ASD by 2014. IACC Recommended Budget: $33,900,000 over 6 years.

Project Link

Project Link

Pathway-based genetic studies of autism spectrum disorder (External web link)

Institution

Institution

University of Pennsylvania

State/Country

State/Country

Pennsylvania

Project Number

Project Number

6286

Federal or Private?

Federal or Private?

Private

Received ARRA Funding?

Received ARRA Funding?

No

History/Related Projects

History/Related Projects

Pathway-based genetic studies of autism spectrum disorder | 34437 | 2010 | 6286
Pathway-based genetic studies of autism spectrum disorder | 60000 | 2008 | 6286

 
Back to Top